Inositol polyphosphate phosphatases C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Members of this family exhibit phosphatase activity towards IP3, as well as towards other inositol derivatives, including the phospholipids PIP2 and PIP3. With IP3 as substrate, 1-phosphatase (EC 3.1.3.57) generates 4,5,-IP2, 4-phosphatases (EC 3.1.3.66, ENSFM00250000001432) generate 1,5,-IP2 and 5-phosphatases (E.C. 3.1.3.36 or 3.1.3.56) generate 1,4,-IP2.

Enzymes

INPP1 Show summary »

INPP4A Show summary »

INPP4B Show summary »

INPP5A Show summary »

INPP5B Show summary »

SHIP1 (INPP5D) Show summary » More detailed page

INPP5E Show summary »

INPP5J Show summary »

INPP5K Show summary »

INPPL1 Show summary »

OCRL Show summary »

SYNJ1 Show summary »

SYNJ2 Show summary »

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References

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How to cite this family page

Database page citation:

Inositol polyphosphate phosphatases. Accessed on 25/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=281.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.