Inositol monophosphatase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Inositol monophosphatase (E.C. 3.1.3.25, IMPase, myo-inositol-1(or 4)-phosphate phosphohydrolase) is a magnesium-dependent homodimer which hydrolyses myo-inositol monophosphate to generate myo-inositol and phosphate. Glycerol may be a physiological phosphate acceptor. Li+ is a nonselective un-competitive inhibitor more potent at IMPase 1 (pKi ca. 3.5, [3]; pIC50 3.2, [4]) than IMPase 2 (pIC50 1.8-2.1, [4]). IMPase activity may be inhibited competitively by L690330 (pKi 5.5, [3]), although the enzyme selectivity is not yet established.

Enzymes

IMPase 1 C Show summary » More detailed page

IMPase 2 C Show summary »

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How to cite this family page

Database page citation:

Inositol monophosphatase. Accessed on 14/12/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=282.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.