Protein kinase C (PKC) C

Overview

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Protein kinase C is the target for the tumour-promoting phorbol esters, such as tetradecanoyl-β-phorbol acetate (TPA, also known as phorbol 12-myristate 13-acetate).

Classical protein kinase C isoforms: PKCα, PKCβ, PKCγ. Members of the classical protein kinase C family are activated by Ca2+ and diacylglycerol, and may be inhibited by GF109203X, calphostin C, Gö 6983, chelerythrine and Ro31-8220.

Novel protein kinase C isoforms: PKCδ, PKCε, PKCη, PKCθ and PKCμ. Members of the classical protein kinase C family are activated by diacylglycerol and may be inhibited by calphostin C, Gö 6983 and chelerythrine.

Atypical protein kinase C isoforms:PKCι, PKCζ.

Subfamilies

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The Kinome image shown here was obtained from Chartier et al. (2013, <a href='https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3740139/figure/fig-4/' target='_blank'>Figure 4</a>) <a href='https://www.ncbi.nlm.nih.gov/pubmed/23940838' target='_blank'>https://www.ncbi.nlm.nih.gov/pubmed/23940838</a> and has been annotated to show the kinases that are targeted by currently approved kinase inhibitor drugs (last updated in April 2018).

How to cite this family page

Database page citation:

Protein kinase C (PKC). Accessed on 16/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=286.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.