IL-2 receptor family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The IL-2 receptor family consists of one or more ligand-selective subunits, and a common γ chain (γc): IL2RG, P31785), though IL-4 and IL-7 receptors can form complexes with other receptor chains. Receptors of this family associate with Jak1 and Jak3, primarily activating Stat5, although certain family members can also activate Stat1, Stat3, or Stat6. Ro264550 has been described as a selective IL-2 receptor antagonist, which binds to IL-2 [4].

Receptors

Complexes

Interleukin-2 receptor C Show summary » More detailed page

Interleukin-4 receptor type I C Show summary » More detailed page

Interleukin-4 receptor type II C Show summary » More detailed page

Interleukin-7 receptor C Show summary » More detailed page

Interleukin-9 receptor C Show summary » More detailed page

Interleukin-15 receptor C Show summary » More detailed page

Interleukin-21 receptor C Show summary » More detailed page

Thymic stromal lymphopoietin receptor C Show summary » More detailed page

Receptors and Subunits

Interleukin 13 receptor, α2 C Show summary » More detailed page

Interleukin-2 receptor subunit α C Show summary » More detailed page

Interleukin-2 receptor subunit β C Show summary » More detailed page

Interleukin-2 receptor subunit γ C Show summary » More detailed page

Interleukin-4 receptor subunit α C Show summary » More detailed page

Interleukin-7 receptor subunit α C Show summary » More detailed page

Interleukin 9 receptor C Show summary » More detailed page

Interleukin-13 receptor subunit α1 C Show summary » More detailed page

Interleukin-15 receptor subunit α C Show summary » More detailed page

Interleukin 21 receptor C Show summary » More detailed page

Cytokine receptor-like factor 2 C Show summary » More detailed page

References

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How to cite this family page

Database page citation:

IL-2 receptor family. Accessed on 25/06/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=305.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.