IL-2 receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The IL-2 receptor family consists of one or more ligand-selective subunits, and a common γ chain (γc): IL2RG, P31785), though IL-4 and IL-7 receptors can form complexes with other receptor chains. Receptors of this family associate with Jak1 and Jak3, primarily activating Stat5, although certain family members can also activate Stat1, Stat3, or Stat6. Ro264550 has been described as a selective IL-2 receptor antagonist, which binds to IL-2 [2].

Receptors

Interleukin-2 receptor Show summary »

Interleukin-4 receptor type I Show summary »

Interleukin-4 receptor type II Show summary »

Interleukin-7 receptor Show summary »

Interleukin-9 receptor Show summary »

Interleukin 13 receptor, α2 Show summary »

Interleukin-15 receptor Show summary »

Interleukin-21 receptor Show summary »

Thymic stromal lymphopoietin receptor Show summary »

Subunits

Interleukin-2 receptor α subunit Show summary »

Interleukin-2 receptor β subunit Show summary »

Interleukin-2 receptor γ subunit Show summary »

Interleukin 4 receptor Show summary »

Interleukin 7 receptor Show summary »

Interleukin 9 receptor Show summary »

Interleukin 13 receptor, α1 Show summary »

Interleukin 15 receptor, α subunit Show summary »

Interleukin 21 receptor Show summary »

Cytokine receptor-like factor 2 Show summary »

References

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How to cite this family page

Database page citation:

IL-2 receptor family. Accessed on 21/11/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=305.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Catalytic Receptors. Br J Pharmacol. 170: 1676–1705.