Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family C

Formerly known as: TAM (or AXL) receptor family

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Members of this RTK family represented a novel structural motif, when sequenced. The ligands for this family, growth arrest specific protein 6 (GAS6, Q14393) and protein S (PROS1, P07225), are secreted plasma proteins which undergo vitamin K-dependent post-translational modifications generating carboxyglutamate-rich domains which are able to bind to negatively-charged surfaces of apoptotic cells.

Receptors

Axl (AXL receptor tyrosine kinase) C Show summary » More detailed page

Tyro3 (TYRO3 protein tyrosine kinase) C Show summary » More detailed page

Mer (MER proto-oncogene, tyrosine kinase) C Show summary » More detailed page

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How to cite this family page

Database page citation:

Type XI RTKs: TAM (TYRO3-, AXL- and MER-TK) receptor family. Accessed on 25/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=328.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Catalytic receptors. Br J Pharmacol. 172: 5979-6023.