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Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
A mouse stromal cell cDNA library was used to clone C2.3 , later termed Rag1-activating protein 1, with a sequence homology predictive of a 4TM topology. The plant orthologues, termed SWEETs, appear to be 7 TM proteins, with extracellular N-termini, and the capacity for bidirectional flux of D-glucose . Expression of mouse SWEET in the mammary gland was suggestive of a role in Golgi lactose synthesis .
* Key recommended reading is highlighted with an asterisk
* Wright EM. (2013) Glucose transport families SLC5 and SLC50. Mol. Aspects Med., 34 (2-3): 183-96. [PMID:23506865]
* Wright EM, Loo DD, Hirayama BA. (2011) Biology of human sodium glucose transporters. Physiol. Rev., 91 (2): 733-94. [PMID:21527736]
1. Chen LQ, Hou BH, Lalonde S, Takanaga H, Hartung ML, Qu XQ, Guo WJ, Kim JG, Underwood W, Chaudhuri B et al.. (2010) Sugar transporters for intercellular exchange and nutrition of pathogens. Nature, 468 (7323): 527-32. [PMID:21107422]
2. Tagoh H, Kishi H, Muraguchi A. (1996) Molecular cloning and characterization of a novel stromal cell-derived cDNA encoding a protein that facilitates gene activation of recombination activating gene (RAG)-1 in human lymphoid progenitors. Biochem. Biophys. Res. Commun., 221 (3): 744-9. [PMID:8630032]
Database page citation:
SLC50 sugar transporter. Accessed on 23/03/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=336.
Concise Guide to PHARMACOLOGY citation:
Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.