More information on this family may be found on the IUPHAR-DB family and introduction pages.
Neurotensin receptors (provisional nomenclature, [2]) are activated by the endogenous tridecapeptide neurotensin (pGlu-Leu-Tyr-Glu-Asn-Lys-Pro-Arg-Arg-Pro-Tyr-Ile-Leu) derived from a precursor (ENSG00000133636), which also generates neuromedin N, an agonist at the NTS2 receptor. A nonpeptide antagonist, SR142948A, shows high affinity (pKi∼9) at both NTS1 and NTS2 receptors [3]. [3H]neurotensin (human, mouse, rat) and [125I]neurotensin (human, mouse, rat) may be used to label NTS1 and NTS2 receptors at 0.1–0.3 and 3–5 nM concentrations respectively.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors 
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Antonelli, T; Fuxe, K; Tomasini, MC; Mazzoni, E; Agnati, LF; Tanganelli, S; Ferraro, L. (2007) Neurotensin receptor mechanisms and its modulation of glutamate transmission in the brain: relevance for neurodegenerative diseases and their treatment. Prog. Neurobiol., 83 (2): 92-109. [PMID:17673354]
Boules, M; Shaw, A; Fredrickson, P; Richelson, E. (2007) Neurotensin agonists: potential in the treatment of schizophrenia. CNS Drugs, 21 (1): 13-23. [PMID:17190526]
Ferraro, L; Tomasini, MC; Mazza, R; Fuxe, K; Fournier, J; Tanganelli, S; Antonelli, T. (2008) Neurotensin receptors as modulators of glutamatergic transmission. Brain Res Rev, 58 (2): 365-73. [PMID:18096238]
Foord, S. M., Bonner, T. I., Neubig, R. R., Rosser, E. M., Pin, J. P., Davenport, A. P., Spedding, M. and Harmar, A. J. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]
Hwang, JI; Kim, DK; Kwon, HB; Vaudry, H; Seong, JY. (2009) Phylogenetic history, pharmacological features, and signal transduction of neurotensin receptors in vertebrates. Ann. N. Y. Acad. Sci., 1163: 169-78. [PMID:19456337]
1. Botto, J. M., Guillemare, E., Vincent, J. P. and Mazella, J. (1997) Effects of SR 48692 on neurotensin-induced calcium-activated chloride currents in the Xenopus oocyte expression system: agonist-like activity on the levocabastine-sensitive neurotensin receptor and absence of antagonist effect on the levocabastine insensitive neurotensin receptor. Neurosci Lett, 223: 193-196. [PMID:9080465]
2. Foord, S. M., Bonner, T. I., Neubig, R. R., Rosser, E. M., Pin, J. P., Davenport, A. P., Spedding, M. and Harmar, A. J. (2005) International Union of Pharmacology. XLVI. G protein-coupled receptor list. Pharmacol Rev, 57: 279-288. [PMID:15914470]
3. Gully, D., Labeeuw, B., Boigegrain, R., Oury-Donat, F., Bachy, A., Poncelet, M., Steinberg, R., Suaud-Chagny, M. F., Santucci, V., Vita, N., Pecceu, F., Labbé-Jullié, C., Kitabgi, P., Soubrie, P., Le Fur, G. and Maffrand, J. P. (1997) Biochemical and pharmacological activities of SR 142948A, a new potent neurotensin receptor antagonist. J Pharmacol Exp Ther, 280: 802-812. [PMID:9023294]
4. Hermans, E., Geurts, M. and Maloteaux, J. M. (1997) Agonist and antagonist modulation of [35S]-GTP gamma S binding in transfected CHO cells expressing the neurotensin receptor. Br J Pharmacol, 121: 1817-1823. [PMID:9283723]
5. Martin, S; Navarro, V; Vincent, JP; Mazella, J. (2002) Neurotensin receptor-1 and -3 complex modulates the cellular signaling of neurotensin in the HT29 cell line. Gastroenterology, 123 (4): 1135-43. [PMID:12360476]
6. Mazella, J., Botto, J. M., Guillemare, E., Coppola, T., Sarret, P. and Vincent, J. P. (1996) Structure, functional expression, and cerebral localization of the levocabastine-sensitive neurotensin/neuromedin N receptor from mouse brain. J Neurosci, 16: 5613-5620. [PMID:8795617]
7. Nielsen, MS; Jacobsen, C; Olivecrona, G; Gliemann, J; Petersen, CM. (1999) Sortilin/neurotensin receptor-3 binds and mediates degradation of lipoprotein lipase. J. Biol. Chem., 274 (13): 8832-6. [PMID:10085125]
8. Richard, F., Barroso, S., Martinez, J., Labbé-Jullié, C. and Kitabgi, P. (2001) Agonism, inverse agonism, and neutral antagonism at the constitutively active human neurotensin receptor 2. Mol Pharmacol, 60: 1392-1398. [PMID:11723247]
9. Souazé, F; Rostène, W; Forgez, P. (1997) Neurotensin agonist induces differential regulation of neurotensin receptor mRNA. Identification of distinct transcriptional and post-transcriptional mechanisms. J. Biol. Chem., 272 (15): 10087-94. [PMID:9092553]
10. Vita, N., Oury-Donat, F., Chalon, P., Guillemot, M., Kaghad, M., Bachy, A., Thurneyssen, O., Garcia, S., Poinot-Chazel, C., Casellas, P., Keane, P., Le Fur, G., Maffrand, J. P., Soubrie, P., Caput, D. and Ferrara, P. (1998) Neurotensin is an antagonist of the human neurotensin NT2 receptor expressed in Chinese hamster ovary cells. Eur J Pharmacol, 360: 265-272. [PMID:9851594]
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neurotensin appears to be a low-efficacy agonist at the NTS2 receptor [10], while the NTS1 receptor antagonist SR48692 is an agonist at NTS2 receptors [10]. An additional protein, provisionally termed NTS3 (also known as NTR3, gp95 and sortilin; ENSG00000134243), has been suggested to bind lipoprotein lipase and mediate its degradation [7]. It has been reported to interact with the NTS1 receptor [5] and has been implicated in hormone trafficking and/or neurotensin uptake.