p38 subfamily

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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p38 MAP kinase is a ubiquitous, highly conserved enzyme which regulates the production of proinflammatory mediators (such as TNFα and IL-1) in response to inflammatory cytokines or environmental stress [6,12-13]. Four p38 MAP kinase homologs have been identified, as have the upstream and downstream signalling mechanisms and enzyme substrates [5,8,15]. Inhibition of these enzymes reduces inflammatory cytokine synthesis. p38 MAP kinase enzymes are therefore highly pursued drug targets for conditions including inflammation, arthritis and other joint diseases, septic shock, and myocardial injury.

Enzymes

p38α (mitogen-activated protein kinase 14) Show summary » More detailed page

p38β (mitogen-activated protein kinase 11) Show summary » More detailed page

p38γ (mitogen-activated protein kinase 12) Show summary » More detailed page

p38δ (mitogen-activated protein kinase 13) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

p38 subfamily. Accessed on 26/05/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=519.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.