Thyrotropin-releasing hormone receptors
More information on this family may be found on the IUPHAR-DB family and introduction pages.
Thyrotropin-releasing hormone (TRH) receptors (provisional nomenclature) are activated by the endogenous tripeptide TRH (pGlu-His-ProNH2). TRH and TRH analogues fail to distinguish TRH1 and TRH2 receptors [3]. [3H]TRH (human, mouse, rat) is able to label both TRH1 and TRH2 receptors with Kd values of 13 and 9 nM respectively.
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
Receptors 
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Bílek, R; Bičíková, M; Šafařík, L. (2011) TRH-like peptides. Physiol Res, 60 (2): 207-15. [PMID:21114375]
Chiamolera, MI; Wondisford, FE. (2009) Minireview: Thyrotropin-releasing hormone and the thyroid hormone feedback mechanism. Endocrinology, 150 (3): 1091-6. [PMID:19179434]
Engel, S; Gershengorn, MC. (2007) Thyrotropin-releasing hormone and its receptors--a hypothesis for binding and receptor activation. Pharmacol. Ther., 113 (2): 410-9. [PMID:17123625]
Gáspár, E; Hardenbicker, C; Bodó, E; Wenzel, B; Ramot, Y; Funk, W; Kromminga, A; Paus, R. (2010) Thyrotropin releasing hormone (TRH): a new player in human hair-growth control. FASEB J., 24 (2): 393-403. [PMID:19825978]
Kamath, J; Yarbrough, GG; Prange, AJ; Winokur, A. (2009) The thyrotropin-releasing hormone (TRH)-immune system homeostatic hypothesis. Pharmacol. Ther., 121 (1): 20-8. [PMID:19000920]
Kleinau, G; Krause, G. (2009) Thyrotropin and homologous glycoprotein hormone receptors: structural and functional aspects of extracellular signaling mechanisms. Endocr. Rev., 30 (2): 133-51. [PMID:19176466]
1. Drummond, AH; Hughes, PJ; Ruiz-Larrea, F; Joels, LA. (1989) Use of receptor antagonist in elucidating the mechanism of action of TRH in GH3 cells. Ann. N. Y. Acad. Sci., 553: 197-204. [PMID:2566295]
2. Straub, R. E., Frech, G. C., Joho, R. H. and Gershengorn, M. C. (1990) Expression cloning of a cDNA encoding the mouse pituitary thyrotropin-releasing hormone receptor. Proc Natl Acad Sci U S A, 87: 9514-9518. [PMID:2175902]
3. Sun, Y; Lu, X; Gershengorn, MC. (2003) Thyrotropin-releasing hormone receptors -- similarities and differences. J. Mol. Endocrinol., 30 (2): 87-97. [PMID:12683933]
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The human orthologue of the rodent TRH2 receptor has yet to be identified.