Acid ceramidase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

Acid ceramidase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The six human ceramidases may be divided on the basis of pH optimae into acid, neutral and alkaline ceramidases, which also differ in their subcellular location.

Enzymes

N-acylsphingosine amidohydrolase 1 C Show summary »« Hide summary

Target Id

2491

Nomenclature

N-acylsphingosine amidohydrolase 1

Previous and unofficial names

AC | ACDase | Acylsphingosine deacylase | N-acylsphingosine amidohydrolase (acid ceramidase) 1

Genes

ASAH1 (Hs), Asah1 (Mm), Asah1 (Rn)

Ensembl ID

ENSG00000104763 (Hs), ENSMUSG00000031591 (Mm), ENSRNOG00000010034 (Rn)

UniProtKB AC

Q13510 (Hs), Q9WV54 (Mm), Q6P7S1 (Rn)

EC number

3.5.1.23

ceramide -> sphingosine + a fatty acid

Comment

This lysosomal enzyme is proteolysed to form the mature protein made up of two chains from the same gene product [1].

References

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How to cite this family page

Database page citation:

Acid ceramidase. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=769.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.