Sphingomyelin synthase | Enzymes | IUPHAR/BPS Guide to PHARMACOLOGY

Sphingomyelin synthase C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Following translocation from the ER to the Golgi under the influence of the ceramide transfer protein, sphingomyelin synthases allow the formation of sphingomyelin by the transfer of phosphocholine from the phospholipid phosphatidylcholine.

Sphingomyelin synthase-related protein 1 is structurally related but lacks sphingomyelin synthase activity.

Enzymes

sphingomyelin synthase 1 C Show summary »« Hide summary More detailed page

Target Id

2520

Nomenclature

sphingomyelin synthase 1

Previous and unofficial names

Phosphatidylcholine:ceramide cholinephosphotransferase 1 | Protein Mob | SMS1 | TMEM23 | transmembrane protein 23

Genes

SGMS1 (Hs), Sgms1 (Mm), Sgms1 (Rn)

Ensembl ID

ENSG00000198964 (Hs), ENSMUSG00000040451 (Mm), ENSRNOG00000012536 (Rn)

UniProtKB AC

Q86VZ5 (Hs), Q8VCQ6 (Mm), Q7TSX5 (Rn)

EC number

2.7.8.27

ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Inhibitors

compound 1j [PMID: 26314925] pIC₅₀ 5.7 [2]

sphingomyelin synthase 2 C Show summary »« Hide summary More detailed page

Target Id

2521

Nomenclature

sphingomyelin synthase 2

Previous and unofficial names

Phosphatidylcholine:ceramide cholinephosphotransferase 2 | SMS2

Genes

SGMS2 (Hs), Sgms2 (Mm), Sgms2 (Rn)

Ensembl ID

ENSG00000164023 (Hs), ENSMUSG00000050931 (Mm), ENSRNOG00000011284 (Rn)

UniProtKB AC

Q8NHU3 (Hs), Q9D4B1 (Mm), Q4JM44 (Rn)

EC number

2.7.8.27

ceramide + phosphatidylcholine -> sphingomyelin + diacylglycerol

Inhibitors

compound D24 [PMID: 24374347] pIC₅₀ 4.9 [1]

Comment

Palmitoylation of sphingomyelin synthase 2 may allow targeting to the plasma membrane [3].

sterile alpha motif domain containing 8 C Show summary »« Hide summary

References

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1. Deng X, Lin F, Zhang Y, Li Y, Zhou L, Lou B, Li Y, Dong J, Ding T, Jiang X et al.. (2014) Identification of small molecule sphingomyelin synthase inhibitors. Eur J Med Chem, 73: 1-7. [PMID:24374347]

2. Li YL, Qi XY, Jiang H, Deng XD, Dong YP, Ding TB, Zhou L, Men P, Chu Y, Wang RX et al.. (2015) Discovery, synthesis and biological evaluation of 2-(4-(N-phenethylsulfamoyl)phenoxy)acetamides (SAPAs) as novel sphingomyelin synthase 1 inhibitors. Bioorg. Med. Chem., 23 (18): 6173-84. [PMID:26314925]

3. Tani M, Kuge O. (2009) Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes. Biochem. Biophys. Res. Commun., 381 (3): 328-32. [PMID:19233134]

How to cite this family page

Database page citation:

Sphingomyelin synthase. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=774.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.