Type XV RTKs: RYK | Catalytic receptors | IUPHAR/BPS Guide to PHARMACOLOGY

Type XV RTKs: RYK C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The ‘related to tyrosine kinase receptor’ (Ryk) is structurally atypical of the family of RTKs, particularly in the activation and ATP-binding domains. RYK has been suggested to lack kinase activity and appears to be involved, with FZD8, in the Wnt signalling system [1].

Receptors

RYK (receptor like tyrosine kinase) C Show summary »« Hide summary More detailed page go icon to follow link

Target Id

1849

Nomenclature

receptor like tyrosine kinase

Common abbreviation

RYK

Previous and unofficial names

RYK1 | receptor-like tyrosine kinase | ERK-3 | Vik

Genes

RYK (Hs), Ryk (Mm), Ryk (Rn)

Ensembl ID

ENSG00000163785 (Hs), ENSMUSG00000032547 (Mm), ENSRNOG00000008593 (Rn)

UniProtKB AC

P34925 (Hs), Q01887 (Mm)

EC number

2.7.10.1

Comments

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References

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How to cite this family page

Database page citation:

Type XV RTKs: RYK. Accessed on 18/04/2024. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=795.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA et al. (2023) The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Br J Pharmacol. 180 Suppl 2:S241-288.