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The zinc-activated channel [ZAC, nomenclature as agreed by the NC-IUPHAR Subcommittee for the zinc activated channel] is a member of the Cys-loop family that includes the nicotinic acetylcholine, 5-HT3, GABAA and strychnine-sensitive glycine receptors [1-2]. The channel is likely to exist as a homopentamer of 4TM subunits that form an intrinsic cation selective channel displaying constitutive activity that can be blocked by (+)-tubocurarine . ZAC is present in the human, chimpanzee, dog, cow and opossum genomes, but is functionally absent from mouse, or rat, genomes [1-2].
Unless otherwise stated all data refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).
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References Show »
1. Davies, PA; Wang, W; Hales, TG; Kirkness, EF. (2003) A novel class of ligand-gated ion channel is activated by Zn2+. J. Biol. Chem., 278 (2): 712-7. [PMID:12381728]
2. Houtani, T; Munemoto, Y; Kase, M; Sakuma, S; Tsutsumi, T; Sugimoto, T. (2005) Cloning and expression of ligand-gated ion-channel receptor L2 in central nervous system. Biochem. Biophys. Res. Commun., 335 (2): 277-85. [PMID:16083862]