Patched family | Transporters | IUPHAR/BPS Guide to PHARMACOLOGY

Patched family C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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NPC1L1 acts in the gut epithelium to allow the accumulation of dietary cholesterol through a clathrin-dependent mechanism. Ezetimibe is used to reduce cholesterol absorption through inhibition of NPC1L1.

Transporters

NPC1 like intracellular cholesterol transporter 1 C Show summary »« Hide summary More detailed page

Target Id

2629

Nomenclature

NPC1 like intracellular cholesterol transporter 1

Previous and unofficial names

Niemann-Pick C1-like protein 1 | NPC1-like 1 | NPC1 like 1

Genes

NPC1L1 (Hs), Npc1l1 (Mm), Npc1l1 (Rn)

Ensembl ID

ENSG00000015520 (Hs), ENSMUSG00000020447 (Mm), ENSRNOG00000049955 (Rn)

UniProtKB AC

Q9UHC9 (Hs), Q6T3U4 (Mm), Q6T3U3 (Rn)

Selective antagonists

ezetimibe (Inhibition) pK_d 6.7 [1]

References

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How to cite this family page

Database page citation:

Patched family. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=856.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Transporters. Br J Pharmacol. 172: 6110-6202.