Kelch-like proteins

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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Keap1 is involved in the Keap1-Nrf2-ARE signaling pathway that is essential for protecting cells from oxidative stress. Nrf2 = nuclear factor erythroid 2-related factor 2; ARE = antioxidant response elements.

Targets

kelch like ECH-associated protein 1 Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Kelch-like proteins. Accessed on 24/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=876.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.