1.17.4.1 Ribonucleoside-diphosphate reductases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Enzymes

ribonucleotide reductase catalytic subunit M1 C Show summary »« Hide summary More detailed page

ribonucleotide reductase regulatory subunit M2 C Show summary »« Hide summary More detailed page

ribonucleotide reductase regulatory TP53 inducible subunit M2B C Show summary »« Hide summary More detailed page

Target Id

2754

Nomenclature

ribonucleotide reductase regulatory TP53 inducible subunit M2B

Previous and unofficial names

ribonucleotide reductase M2 B (TP53 inducible)

Genes

RRM2B (Hs), Rrm2b (Mm), Rrm2b (Rn)

Ensembl ID

ENSG00000048392 (Hs), ENSMUSG00000022292 (Mm)

UniProtKB AC

Q7LG56 (Hs), Q6PEE3 (Mm)

EC number

1.17.1.4

References

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1. Heinemann V, Xu YZ, Chubb S, Sen A, Hertel LW, Grindey GB, Plunkett W. (1990) Inhibition of ribonucleotide reduction in CCRF-CEM cells by 2',2'-difluorodeoxycytidine. Mol. Pharmacol., 38 (4): 567-72. [PMID:2233693]

2. Parker WB, Shaddix SC, Chang CH, White EL, Rose LM, Brockman RW, Shortnacy AT, Montgomery JA, Secrist 3rd JA, Bennett Jr LL. (1991) Effects of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl)adenine on K562 cellular metabolism and the inhibition of human ribonucleotide reductase and DNA polymerases by its 5'-triphosphate. Cancer Res., 51 (9): 2386-94. [PMID:1707752]

3. Shao J, Zhou B, Zhu L, Bilio AJ, Su L, Yuan YC, Ren S, Lien EJ, Shih J, Yen Y. (2005) Determination of the potency and subunit-selectivity of ribonucleotide reductase inhibitors with a recombinant-holoenzyme-based in vitro assay. Biochem. Pharmacol., 69 (4): 627-34. [PMID:15670581]

4. Tseng WC, Derse D, Cheng YC, Brockman RW, Bennett Jr LL. (1982) In vitro biological activity of 9-beta-D-arabinofuranosyl-2-fluoroadenine and the biochemical actions of its triphosphate on DNA polymerases and ribonucleotide reductase from HeLa cells. Mol. Pharmacol., 21 (2): 474-7. [PMID:7048062]

How to cite this family page

Database page citation:

1.17.4.1 Ribonucleoside-diphosphate reductases. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=877.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.