1.4.3.13 Lysyl oxidases

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

GtoImmuPdb view: OFF

Enzymes

lysyl oxidase like 2 Show summary »« Hide summary More detailed page

Target Id

2853

Nomenclature

lysyl oxidase like 2

Previous and unofficial names

LOR2 | WS9-14 | protein-lysine 6-oxidase | lysyl oxidase homolog 2 | lysyl oxidase-like 2

Genes

LOXL2 (Hs), Loxl2 (Mm), Loxl2 (Rn)

Ensembl ID

ENSG00000134013 (Hs), ENSMUSG00000034205 (Mm), ENSRNOG00000016758 (Rn)

UniProtKB AC

Q9Y4K0 (Hs), P58022 (Mm), B5DF27 (Rn)

EC number

1.4.3.13
Reaction is required for collagen and elastin cross-linking in the biosynthesis of normal mature extracellular matrices. peptidyl-L-lysyl-peptide + O₂ + H₂O = peptidyl-allysyl-peptide + NH₃ + H₂O₂ [1]

References

Show »« Hide

How to cite this family page

Database page citation:

1.4.3.13 Lysyl oxidases. Accessed on 12/07/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=912.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.