3.5.3.15 Peptidyl arginine deiminases (PADI) C

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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In humans, the peptidyl arginine deiminases (PADIs; HGNC family link) are a family of five enzymes, PADI1-4 and PADI6. PADIs catalyze the deimination of protein L-arginine residues to L-citrulline and ammonia, generating peptidyl-citrulline on histones, fibrinogen, and other biologically relevant proteins. The human isozymes exhibit tissue-specific expression patterns [2]. Overexpression and/or increased PADI activity is observed in several diseases, including rheumatoid arthritis, Alzheimer's disease, multiple sclerosis, lupus, Parkinson's disease, and cancer [1]. Pharmacological PADI inhibition reverses protein-hypercitrullination and disease in mouse models of multiple sclerosis [4].

Enzymes

peptidyl arginine deiminase 1 Show summary » More detailed page

peptidyl arginine deiminase 3 Show summary » More detailed page

peptidyl arginine deiminase 4 Show summary » More detailed page

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How to cite this family page

Database page citation:

3.5.3.15 Peptidyl arginine deiminases (PADI). Accessed on 20/10/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=918.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Enzymes. Br J Pharmacol. 174 Suppl 1: S272-S359.