Fc epsilon receptors

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Overview

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The type I high affinity IgE receptor (FCεRI) is crucial for the production of allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. The FCεRII has a lower affinity for IgE.

Targets

FCεR1α (Fc fragment of IgE receptor Ia) Show summary » More detailed page

FCεR1β (membrane spanning 4-domains A2) Show summary » More detailed page

FCεR1γ (Fc fragment of IgE receptor Ig) Show summary » More detailed page

FCεRII (Fc fragment of IgE receptor II) Show summary » More detailed page

How to cite this family page

Database page citation:

Fc epsilon receptors. Accessed on 16/08/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=946.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.