Antimalarial targets

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Targets

PfATP4 (Plasmodium falciparum ATPase4) Show summary »« Hide summary More detailed page

Target Id	2971
Nomenclature	Plasmodium falciparum ATPase4
Common abbreviation	PfATP4
Previous and unofficial names	P-type ATPase4
Genes	ATP4 (Pf3D7)
UniProtKB AC	A0A143ZZK9 (Pf3D7)

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) Show summary »« Hide summary More detailed page

Target Id	2954
Nomenclature	Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit
Common abbreviation	PfcPheRS
Previous and unofficial names	Pfal cPheRS
Genes	cPheRS (Pf3D7)
UniProtKB AC	Q8I246 (Pf3D7)

PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase) Show summary »« Hide summary More detailed page

Target Id

2981

Nomenclature

Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase

Common abbreviation

PfDHFR-TS

Genes

DHFR-TS (Pf3D7)

UniProtKB AC

Q8I1R6 (Pf3D7)

Whole Organism Data Linked to Target

pyrimethamine pIC₅₀ 7.2 ([³H]-hypoxanthine incorporation assay wild-type P. falciparum (TM4)) [3] - Plasmodium falciparum TM4

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) Show summary »« Hide summary More detailed page

Target Id

2949

Nomenclature

Plasmodium falciparum dihydroorotate dehydrogenase

Common abbreviation

PfDHODH

Previous and unofficial names

Pfal DHODH

Genes

DHODH (Pf3D7)

UniProtKB AC

Q08210 (Pf3D7)

Whole Organism Data Linked to Target

DSM265 pIC₅₀ 7.5 ([³H]-hypoxanthine incorporation) [2] - Plasmodium falciparum NF54

PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase) Show summary »« Hide summary More detailed page

Target Id	2980
Nomenclature	Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Common abbreviation	PfDXR
Previous and unofficial names	DOXR
Genes	DXR (Pf3D7)
UniProtKB AC	Q8IKG4 (Pf3D7)

PfeEF2 (Plasmodium falciparum elongation factor 2) Show summary »« Hide summary More detailed page

Target Id	2975
Nomenclature	Plasmodium falciparum elongation factor 2
Common abbreviation	PfeEF2
Genes	eEF2 (Pf3D7)
UniProtKB AC	Q8IKW5 (Pf3D7)

PfNMT (Plasmodium falciparum N-Myristoyltransferase) Show summary »« Hide summary More detailed page

Target Id	2955
Nomenclature	Plasmodium falciparum N-Myristoyltransferase
Common abbreviation	PfNMT
Previous and unofficial names	Pfal NMT
Genes	NMT (Pf3D7)
UniProtKB AC	Q8ILW6 (Pf3D7)

PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase) Show summary »« Hide summary More detailed page

Target Id

2972

Nomenclature

Plasmodium falciparum phosphatidylinositol 4-kinase

Common abbreviation

PfPI4K

Genes

PI4K (Pf3D7)

UniProtKB AC

Q8I406 (Pf3D7)

Whole Organism Data Linked to Target

MMV048 pIC₅₀ 7.6 ([³H]-hypoxanthine incorporation assay) [1] - Plasmodium falciparum NF54

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) Show summary »« Hide summary More detailed page

Target Id	3013
Nomenclature	Plasmodium falciparum cGMP-dependent protein kinase
Common abbreviation	PfPKG
Genes	PKG (Pf3D7)
UniProtKB AC	Q8I719 (Pf3D7)

References

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1. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med, 9 (387). [PMID:28446690]

2. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S et al.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7 (296): 296ra111. [PMID:26180101]

3. Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E et al.. (2012) Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc. Natl. Acad. Sci. U.S.A., 109 (42): 16823-8. [PMID:23035243]

How to cite this family page

Database page citation:

Antimalarial targets. Accessed on 17/01/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.