Anti-infective targets

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

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Targets

Pfal DHODH (Plasmodium falciparum dihydroorotate dehydrogenase) Show summary »« Hide summary More detailed page

Target Id

2949

Nomenclature

Plasmodium falciparum dihydroorotate dehydrogenase

Common abbreviation

Pfal DHODH

Genes

DHODH (Pfal)

UniProtKB AC

Q08210 (Pfal)

Selective inhibitors

DSM265 pIC₅₀ 7.5 [2] - Plasmodium falciparum

MTB polyketide synthase Pks13 Show summary »« Hide summary More detailed page

Target Id

2950

Nomenclature

MTB polyketide synthase Pks13

UniProtKB AC

I6X8D2 (TB)

Selective inhibitors

TAM16 pIC₅₀ 6.7 [1] - Mycobacterium tuberculosis

Hepatitis C virus genome polyprotein Show summary »« Hide summary More detailed page

Target Id

2952

Systematic nomenclature

Hepatitis C virus genome polyprotein

UniProtKB AC

Q6GYR8

Selective inhibitors

simeprevir pK_i 9.4 [3] - Hepatitis C virus

Zika virus genome polyprotein / Zika virus (strain Mr 766) (ZIKV) polyprotein Show summary »« Hide summary More detailed page

Target Id

2953

Nomenclature

Zika virus genome polyprotein

Systematic nomenclature

Zika virus (strain Mr 766) (ZIKV) polyprotein

UniProtKB AC

A0A140DLX4

Ligands

NSC157058 pIC₅₀ [4]

Pfal cPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) Show summary »« Hide summary More detailed page

Target Id	2954
Nomenclature	Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit
Common abbreviation	Pfal cPheRS
Genes	cPheRS (Pfal)
UniProtKB AC	Q8I246 (Pfal)

Pfal NMT (Plasmodium falciparum N-Myristoyltransferase) Show summary »« Hide summary More detailed page

Target Id	2955
Nomenclature	Plasmodium falciparum N-Myristoyltransferase
Common abbreviation	Pfal NMT
Genes	NMT (Pfal)
UniProtKB AC	Q8ILW6 (Pfal)

References

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1. Aggarwal A, Parai MK, Shetty N, Wallis D, Woolhiser L, Hastings C, Dutta NK, Galaviz S, Dhakal RC, Shrestha R et al.. (2017) Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell, 170 (2): 249-259.e25. [PMID:28669536]

2. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S et al.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7 (296): 296ra111. [PMID:26180101]

3. Raboisson P, de Kock H, Rosenquist A, Nilsson M, Salvador-Oden L, Lin TI, Roue N, Ivanov V, Wähling H, Wickström K et al.. (2008) Structure-activity relationship study on a novel series of cyclopentane-containing macrocyclic inhibitors of the hepatitis C virus NS3/4A protease leading to the discovery of TMC435350. Bioorg. Med. Chem. Lett., 18 (17): 4853-8. [PMID:18678486]

4. Shiryaev SA, Farhy C, Pinto A, Huang CT, Simonetti N, Ngono AE, Dewing A, Shresta S, Pinkerton AB, Cieplak P et al.. (2017) Characterization of the Zika virus two-component NS2B-NS3 protease and structure-assisted identification of allosteric small-molecule antagonists. Antiviral Res., 143: 218-229. [PMID:28461069]

How to cite this family page

Database page citation:

Anti-infective targets. Accessed on 21/09/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Buneman OP, Catterall WA, Cidlowski JA, Davenport AP, Fabbro D, Fan G, McGrath JC, Spedding M, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Overview. Br J Pharmacol. 172: 5729-5743.