Antimalarial targets

Overview

This family encompasses antimalarial targets identified and validated in Plasmodium, the genus of protozoan parasite known to cause malaria. The genome of P. falciparum, the species that is responsible for the majority of malaria-related deaths, has been sequenced and analysed contributing to an increased understanding of potential biological targets in the parasite. More than half of the predicted gene products exhibit little homology outside the Plasmodium genus and have not been given functional assignments, while a considerable number are unique to P. falciparum [2]. In recent years, genetic methods have facilitated the identification of new molecular targets in the parasite and it is hoped that novel cross-lifecycle targets will be elucidated to help inform antimalarial drug discovery [1].

Targets

PfATP4 (Plasmodium falciparum ATPase4) Show summary »« Hide summary More detailed page

Target Id	2971
Nomenclature	Plasmodium falciparum ATPase4
Common abbreviation	PfATP4
Previous and unofficial names	P-type ATPase4
Genes	ATP4 (Pf3D7)
UniProtKB AC	A0A143ZZK9 (Pf3D7)

PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase) Show summary »« Hide summary More detailed page

Target Id

2981

Nomenclature

Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase

Common abbreviation

PfDHFR-TS

Genes

DHFR-TS (Pf3D7)

UniProtKB AC

Q8I1R6 (Pf3D7)

Whole Organism Data Linked to Target

pyrimethamine pIC₅₀ 7.2 ([³H]-hypoxanthine incorporation assay wild-type P. falciparum (TM4)) [3] - Plasmodium falciparum TM4

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) Show summary »« Hide summary More detailed page

Target Id	2949
Nomenclature	Plasmodium falciparum dihydroorotate dehydrogenase
Common abbreviation	PfDHODH
Previous and unofficial names	Pfal DHODH
Genes	DHODH (Pf3D7)
UniProtKB AC	Q08210 (Pf3D7)

PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase) Show summary »« Hide summary More detailed page

Target Id	2980
Nomenclature	Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Common abbreviation	PfDXR
Previous and unofficial names	DOXR
Genes	DXR (Pf3D7)
UniProtKB AC	Q8IKG4 (Pf3D7)

PfeEF2 (Plasmodium falciparum elongation factor 2) Show summary »« Hide summary More detailed page

Target Id	2975
Nomenclature	Plasmodium falciparum elongation factor 2
Common abbreviation	PfeEF2
Genes	eEF2 (Pf3D7)
UniProtKB AC	Q8IKW5 (Pf3D7)

PfIspD (Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase) Show summary »« Hide summary More detailed page

Target Id	3064
Nomenclature	Plasmodium falciparum 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Common abbreviation	PfIspD
Genes	IspD (Pf3D7)
UniProtKB AC	Q8I273 (Pf3D7)

PfNMT (Plasmodium falciparum N-Myristoyltransferase) Show summary »« Hide summary More detailed page

Target Id	2955
Nomenclature	Plasmodium falciparum N-Myristoyltransferase
Common abbreviation	PfNMT
Previous and unofficial names	Pfal NMT
Genes	NMT (Pf3D7)
UniProtKB AC	Q8ILW6 (Pf3D7)

PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase) Show summary »« Hide summary More detailed page

Target Id	2972
Nomenclature	Plasmodium falciparum phosphatidylinositol 4-kinase
Common abbreviation	PfPI4K
Genes	PI4K (Pf3D7)
UniProtKB AC	Q8I406 (Pf3D7)

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) Show summary »« Hide summary More detailed page

Target Id	3013
Nomenclature	Plasmodium falciparum cGMP-dependent protein kinase
Common abbreviation	PfPKG
Genes	PKG (Pf3D7)
UniProtKB AC	Q8I719 (Pf3D7)

PfPPPK-DHPS (Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase) Show summary »« Hide summary More detailed page

Target Id	3065
Nomenclature	Plasmodium falciparum hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase
Common abbreviation	PfPPPK-DHPS
Genes	PPPK-DHPS (Pf3D7)
UniProtKB AC	Q8IAU3 (Pf3D7)

PfSHMT (Plasmodium falciparum serine hydroxymethyltransferase) Show summary »« Hide summary More detailed page

Target Id	3066
Nomenclature	Plasmodium falciparum serine hydroxymethyltransferase
Common abbreviation	PfSHMT
Genes	SHMT (Pf3D7)
UniProtKB AC	Q8I566 (Pf3D7)

PfKRS1 (Plasmodium falciparum lysine--tRNA ligase) Show summary »« Hide summary More detailed page

Target Id	3059
Nomenclature	Plasmodium falciparum lysine--tRNA ligase
Common abbreviation	PfKRS1
Previous and unofficial names	Plasmodium falciparum lysyl-tRNA synthetase
Genes	KRS1 (Pf3D7)
UniProtKB AC	Q8IDJ8 (Pf3D7)

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) Show summary »« Hide summary More detailed page

Target Id	2954
Nomenclature	Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit
Common abbreviation	PfcPheRS
Previous and unofficial names	Pfal cPheRS
Genes	cPheRS (Pf3D7)
UniProtKB AC	Q8I246 (Pf3D7)

PfPRS (Plasmodium falciparum proline--tRNA ligase) Show summary »« Hide summary More detailed page

Target Id	3056
Nomenclature	Plasmodium falciparum proline--tRNA ligase
Common abbreviation	PfPRS
Previous and unofficial names	Plasmodium falciparum prolyl-tRNA synthetase \| PfPRORS
Genes	PRS (Pf3D7)
UniProtKB AC	Q8I5R7 (Pf3D7)

PfThrRS (Plasmodium falciparum threonine--tRNA ligase) Show summary »« Hide summary More detailed page

Target Id	3058
Nomenclature	Plasmodium falciparum threonine--tRNA ligase
Common abbreviation	PfThrRS
Previous and unofficial names	Plasmodium falciparum threoninyl-tRNA synthetase
Genes	ThrRS (Pf3D7)
UniProtKB AC	Q8IIA4 (Pf3D7)

References

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1. Flannery EL, Fidock DA, Winzeler EA. (2013) Using genetic methods to define the targets of compounds with antimalarial activity. J. Med. Chem., 56 (20): 7761-71. [PMID:23927658]

2. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S et al.. (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature, 419 (6906): 498-511. [PMID:12368864]

3. Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E et al.. (2012) Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc. Natl. Acad. Sci. U.S.A., 109 (42): 16823-8. [PMID:23035243]

How to cite this family page

Database page citation:

Antimalarial targets. Accessed on 21/03/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.