Antimalarial targets

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Targets

PfATP4 (Plasmodium falciparum ATPase4) Show summary »« Hide summary More detailed page

Target Id	2971
Nomenclature	Plasmodium falciparum ATPase4
Common abbreviation	PfATP4
Previous and unofficial names	P-type ATPase4
Genes	ATP4 (Pf3D7)
UniProtKB AC	A0A143ZZK9 (Pf3D7)

PfcPheRS (Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit) Show summary »« Hide summary More detailed page

Target Id	2954
Nomenclature	Plasmodium falciparum phenylalanine--tRNA ligase alpha subunit
Common abbreviation	PfcPheRS
Previous and unofficial names	Pfal cPheRS
Genes	cPheRS (Pf3D7)
UniProtKB AC	Q8I246 (Pf3D7)

PfDHFR-TS (Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase) Show summary »« Hide summary More detailed page

Target Id	2981
Nomenclature	Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase
Common abbreviation	PfDHFR-TS
Genes	DHFR-TS (Pf3D7)
UniProtKB AC	Q8I1R6 (Pf3D7)

PfDHODH (Plasmodium falciparum dihydroorotate dehydrogenase) Show summary »« Hide summary More detailed page

Target Id	2949
Nomenclature	Plasmodium falciparum dihydroorotate dehydrogenase
Common abbreviation	PfDHODH
Previous and unofficial names	Pfal DHODH
Genes	DHODH (Pf3D7)
UniProtKB AC	Q08210 (Pf3D7)

PfDXR (Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase) Show summary »« Hide summary More detailed page

Target Id	2980
Nomenclature	Plasmodium falciparum 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Common abbreviation	PfDXR
Previous and unofficial names	DOXR
Genes	DXR (Pf3D7)
UniProtKB AC	Q8IKG4 (Pf3D7)

PfeEF2 (Plasmodium falciparum elongation factor 2) Show summary »« Hide summary More detailed page

Target Id	2975
Nomenclature	Plasmodium falciparum elongation factor 2
Common abbreviation	PfeEF2
Genes	eEF2 (Pf3D7)
UniProtKB AC	Q8IKW5 (Pf3D7)

PfNMT (Plasmodium falciparum N-Myristoyltransferase) Show summary »« Hide summary More detailed page

Target Id	2955
Nomenclature	Plasmodium falciparum N-Myristoyltransferase
Common abbreviation	PfNMT
Previous and unofficial names	Pfal NMT
Genes	NMT (Pf3D7)
UniProtKB AC	Q8ILW6 (Pf3D7)

PfPI4K (Plasmodium falciparum phosphatidylinositol 4-kinase) Show summary »« Hide summary More detailed page

Target Id	2972
Nomenclature	Plasmodium falciparum phosphatidylinositol 4-kinase
Common abbreviation	PfPI4K
Genes	PI4K (Pf3D7)
UniProtKB AC	Q8I406 (Pf3D7)

PfPKG (Plasmodium falciparum cGMP-dependent protein kinase) Show summary »« Hide summary More detailed page

Target Id	3013
Nomenclature	Plasmodium falciparum cGMP-dependent protein kinase
Common abbreviation	PfPKG
Genes	PKG (Pf3D7)
UniProtKB AC	Q8I719 (Pf3D7)

References

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1. Paquet T, Le Manach C, Cabrera DG, Younis Y, Henrich PP, Abraham TS, Lee MCS, Basak R, Ghidelli-Disse S, Lafuente-Monasterio MJ et al.. (2017) Antimalarial efficacy of MMV390048, an inhibitor of Plasmodium phosphatidylinositol 4-kinase. Sci Transl Med, 9 (387). [PMID:28446690]

2. Phillips MA, Lotharius J, Marsh K, White J, Dayan A, White KL, Njoroge JW, El Mazouni F, Lao Y, Kokkonda S et al.. (2015) A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria. Sci Transl Med, 7 (296): 296ra111. [PMID:26180101]

3. Yuthavong Y, Tarnchompoo B, Vilaivan T, Chitnumsub P, Kamchonwongpaisan S, Charman SA, McLennan DN, White KL, Vivas L, Bongard E et al.. (2012) Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target. Proc. Natl. Acad. Sci. U.S.A., 109 (42): 16823-8. [PMID:23035243]

How to cite this family page

Database page citation:

Antimalarial targets. Accessed on 26/09/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=970.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA; CGTP Collaborators. (2017) The Concise Guide to PHARMACOLOGY 2017/18: Overview. Br J Pharmacol. 174 Suppl 1: S1-S16.