Gene name | K/O mouse Y/N | Phenotype Y/N | Phenotype description | Reference |
---|---|---|---|---|
BB3 | Yes | Yes | Obesity, hypertension, impaired insulin metabolism | [68,71] |
BB3 | Yes | Yes | Hyperphagia, reduced metabolic rate | [2] |
BB3 | Yes | Yes | Overexpression of melanin concentrating hormone receptors | [53] |
GPR1 | No | No | ||
GPR3 | Yes | Yes | Premature ovarian aging, premature termination of meiotic arrest in oocytes | [40,61] |
GPR3 | Yes | Yes | Low basal intracellualar cAMP levels; increased stress levels | [90] |
GPR4 | Yes | Yes | Metabolic acidosis | [86] |
GPR4 | Yes | Yes | Reduced tumour growth and pathological angiogenesis | [98] |
GPR6 | Yes | Yes | Reduced striatal cAMP production | [47] |
GPR12 | Yes | Yes | Dyslipidemia, higher body weight and fat mass | [7] |
GPR17 | Yes | Yes | Early onset of oligodendrocyte myelination | [12] |
GPR17 | Yes | Yes | Increased susceptibility to pulmonary inflammation | [52] |
GPR18 | No | n/a | ||
GPR15 | No | n/a | ||
GPR19 | Yes | No | ||
GPR20 | Yes | No | ||
GPR21 | Yes | Yes | Resistance to diet-induced obesity, increase in glucose tolerance and insulin sensitivity, modest lean phenotype | [19,73] |
GPR21 | Yes | Yes | Protection from obesity-induced inflammation and insulin resistance, reduced macrophage infiltration into adipose tissue and liver | [73] |
GPR22 | Yes | Yes | Increased response to aortic banding including decreased fractional shortening and decompensated heart failure. | [1] |
GPR25 | No | n/a | ||
GPR26 | Yes | Yes | Increased anxiety and depression-like behaviours | [102] |
GPR27 | No | n/a | ||
GPR27 | ||||
GPR31 | No | n/a | ||
GPR32 | No | n/a | ||
GPR33 | No | n/a | ||
GPR34 | Yes | Yes | Altered immune response in hypersensitivity tests | [45] |
GPR35 | No | n/a | ||
GPR37 | Yes | Yes | Reduced striatal dopamine levels, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females. | [26,56] |
GPR37 | Yes | Yes | Lower lever of endoplasmic reticulum-associated protein degradation (ERAD) and autophagic markers. | [55] |
GPR37L1 | Yes | Yes | High blood pressure and a high heart weight to body weight ratio | [62] |
GPR39 | Yes | Yes | Acceleration of gastric emptying, higher body weight and fat composition and increased cholesterol levels | [63] |
GPR39 | Yes | Yes | Impaired glucose tolerance, decreased insulin response to glucose | [24,89] |
GPR42 | No | n/a | ||
GPR45 | No | n/a | ||
GPR50 | Yes | Yes | Low body weight, partial resistance to diet induced obesity | [28] |
GPR50 | Yes | Yes | Decreased thermogenesis | [5] |
GPR52 | No | n/a | ||
GPR55 | Yes | Yes | Increased bone volume, impaired osteoclast function in male mice | [3,96] |
GPR61 | Yes | No | ||
GPR62 | No | n/a | ||
GPR63 | No | n/a | ||
GPR65 | Yes | Yes | Thermocytes and splenocytes are insensitive to pH-regulated cAMP production | [37,72] |
GPR68 | Yes | Yes | Reduced osteoblast levels and decreased melanoma cell tumorigenesis | [44] |
GPR68 | Yes | Yes | Upregulated expression of Pyk2 and an increase in socdium-hydrogen antiporter activity | [64] |
GPR68 | Yes | Yes | Enhanced SPC-activation of ERK1/2 | [6] |
GPR75 | No | n/a | ||
GPR78 | No | n/a | ||
GPR79 | No | n/a | ||
GPR82 | Yes | Yes | Lower body weight and fat content than wild type, higher insulin sensitivity and glucose tolerance and decreased serum triglycerides | [18] |
GPR83 | Yes | No | ||
GPR84 | Yes | Yes | Increased interleukin (Il-4, IL-5, IL-13) production by Th2 effector cells; increased IL-4 production from T cells treated with anti-CD3 | [91] |
GPR85 | Yes | Yes | Increased brain weight, enhanced neuronal survival in dendrate gyrus, and enhanced ability to discriminate spatial relationships | [11,58] |
GPR87 | Yes | No | ||
GPR88 | Yes | Yes | Higher basal striatal phosphorylated DARPP-21-Thr-34 and lower basal dopamine | [48] |
GPR101 | No | n/a | ||
GPR119 | Yes | Yes | Low body weight and low post-prandial levels of GLP-1 | [38] |
GPR132 | Yes | Yes | Mildly cholestatic phenotype with altered hepatobiliary homeostasis and gall stone formation | [30] |
GPR132 | Yes | Yes | Increase in IL-6 and MCP-1 production and a dramatic increase in nuclear localization of the p65 subunit of nuclear factor κB. Proinflammatory signaling and increased monocyte/endothelial interactions in the aortic wall | [8] |
GPR132 | Yes | Yes | Reduced atherosclerotic plaque stability | [74] |
GPR132 | Yes | Yes | Progressive wasting syndrome in mice > 1 year. Secondary lymphoid organ enlargement associated with lymphocytic infiltration | [39] |
GPR135 | No | n/a | ||
GPR139 | No | n/a | ||
GPR141 | No | n/a | ||
GPR142 | No | n/a | ||
GPR146 | No | n/a | ||
GPR148 | No | n/a | ||
GPR149 | No | n/a | ||
GPR150 | No | n/a | ||
GPR151 | Yes | No | ||
GPR152 | No | n/a | ||
GPR153 | No | n/a | ||
GPR160 | No | n/a | ||
GPR161 | Yes | No | ||
GPR162 | No | n/a | ||
GPR171 | No | n/a | ||
GPR173 | No | n/a | ||
GPR174 | No | n/a | ||
GPR176 | No | n/a | ||
GPR182 | No | n/a | ||
GPR183 | Yes | Yes | Abolished migration of bone-marrow-derived dendritic cells towards 7alpha, 25-dihydroxycholesterol | [21] |
GPR183 | Yes | Yes | Reduction in the early antibody response to a T-dependent antigen | [33,76] |
GPR183 | Yes | Yes | Failure of B-cells to migrate to the outer follicle | [33,76] |
LGR4 | Yes | Yes | Embryonic and perinatal lethality | [59] |
LGR4 | Yes | Yes | Delay in osteoblast differentiation and mineralization | [51] |
LGR4 | Yes | Yes | Impaired eye development | [15] |
LGR4 | Yes | Yes | Reduced keratinocyte and epithelial cell proliferation | [29,32,95] |
LGR4 | Yes | Yes | Renal hypoplasia | [31,65] |
LGR5 | Yes | Yes | Neonatal lethality resulting from ankyloglossia, gastrointestinal distension, cyanosis and respiratory failure. | [66] |
LGR6 | No | n/a | ||
MAS1 | Yes | Yes | Elevated blood pressure and impaired endothelial function | [99] |
MAS1 | Yes | Yes | Increased duration of long term potentiation in the dentate gyrus, increased anxiety and alterations in the onset of depotentiation | [92] |
MAS1 | Yes | Yes | Erectile dysfunction | [14] |
MAS1 | Yes | Yes | Increased sympathetic tone | [93] |
MAS1L | No | n/a | ||
MRGPRD | Yes | Yes | Decreased sensitivity to mechanical, cold, and heat stimuli on a congenic C57BL/6 background | |
MRGPRE | Yes | Yes | Deletion of MRGPRE increases MRGPRF expression in the spinal cord | [13] |
MRGPRF | No | n/a | ||
MRGPRG | No | n/a | ||
MRGPRX1 | No | n/a | ||
MRGPRX2 | No | n/a | ||
MRGPRX3 | No | n/a | ||
MRGPRX4 | No | n/a | ||
OPN3 | No | n/a | ||
OPN4 | Yes | Yes | Impaired pupillary response at high irradiances | [50] |
OPN5 | No | n/a | ||
OXGR1 | Yes | Yes | Otitis media with effusion resulting from histopathological changes in the middle ear epithelium | [34] |
P2RY8 | No | n/a | ||
P2RY10 | No | n/a | ||
SUCNR1 (GPR91) | Yes | Yes | Impaired renin release from the kidney in response to high glucose levels | [88] |
SUCNR1 (GPR91) | Yes | Yes | Abolished induction of hypertension by succinate | [22] |
SUCNR1 (GPR91) | Yes | Yes | Impaired dendritic cell migration, decreased T- cell proliferation and diminished succinate-mediated immune responses | [81] |
TAAR2 | No | n/a | ||
TAAR3 | No | n/a | ||
TAAR4 | No | n/a | ||
TAAR5 | No | n/a | ||
TAAR6 | No | n/a | ||
TAAR8 | No | n/a | ||
TAAR9 | No | n/a |
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