G protein-coupled receptors

Download information on GPCRs as part of our target list in CSV format

Calcium-sensing receptor
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Calcium-sensing receptor Ca2+
Mg2+
CaS receptor CASR
Casr
Casr
Class C Orphans
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Class C Orphans GPR156 GPR156
Gpr156
Gpr156
Class C Orphans GPR158 GPR158
Gpr158
Gpr158
aka KIAA1136
Class C Orphans GPR179 GPR179
Gpr179
Gpr179
Class C Orphans GPRC5A GPRC5A
Gprc5a
Gprc5a
Class C Orphans GPRC5B GPRC5B
Gprc5b
Gprc5b
Class C Orphans GPRC5C GPRC5C
Gprc5c
Gprc5c
Class C Orphans GPRC5D GPRC5D
Gprc5d
Gprc5d
Class C Orphans GPRC6 receptor GPRC6A
Gprc6a
Gprc6a
GABAB receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
GABAB receptors GABA
GABAB1 GABBR1
Gabbr1
Gabbr1
GABAB receptors GABAB2 GABBR2
Gabbr2
Gabbr2
GABAB receptors GABAB receptor Functional GABA receptors contain both GABAB1 and GABAB2 subunits
Metabotropic glutamate receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Metabotropic glutamate receptors L-glutamic acid
mGlu1 receptor GRM1
Grm1
Grm1
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu2 receptor GRM2
Grm2
Grm2
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu3 receptor GRM3
Grm3
Grm3
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu4 receptor GRM4
Grm4
Grm4
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu5 receptor GRM5
Grm5
Grm5
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu6 receptor GRM6
Grm6
Grm6
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu7 receptor GRM7
Grm7
Grm7
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Metabotropic glutamate receptors L-glutamic acid
mGlu8 receptor GRM8
Grm8
Grm8
Other endogenous ligands include L-aspartic acid, L-serine-O-phosphate, NAAG and L-cysteine sulphinic acid
Taste 1 receptors
Family name Ligand Official IUPHAR receptor name Human gene symbol Rat gene symbol Mouse gene symbol Comment
Taste 1 receptors TAS1R1 TAS1R1
Tas1r1
Tas1r1
Taste 1 receptors TAS1R2 TAS1R2
Tas1r2
Taste 1 receptors TAS1R3 TAS1R3
Tas1r3
Tas1r3