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ChEMBL ligand: CHEMBL15245 (Yohimbine, Yohimbinum) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] | ||||||||
ChEMBL | Inhibition of specific [3H]prazosin binding (0.2 nM) to rat brain membranes alpha-1 adrenergic receptor | B | 6.4 | pKd | 398.11 | nM | Kd | J Med Chem (1984) 27: 495-503 [PMID:6142954] |
ChEMBL | Inhibition of [3H]prazosin binding to human Alpha-1A adrenergic receptor expressed in CHO cells | B | 5.98 | pKi | 1057 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130] | ||||||||
ChEMBL | Binding activity against alpha-1 adrenergic receptor from calf cerebral cortex, using [3H]-prazosin as the radioligand | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (1983) 26: 1696-1701 [PMID:6139479] |
ChEMBL | Evaluated for its ability to displace [3H]prazosin from alpha-1-Adrenoceptor of calf cerebral cortex | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (1985) 28: 1756-1759 [PMID:2999400] |
ChEMBL | Displacement of [3H]prazosin from calf cerebral cortex alpha-1 adrenergic receptor | B | 6.7 | pKi | 200 | nM | Ki | J Med Chem (1984) 27: 1182-1185 [PMID:6088770] |
ChEMBL | Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in bovine pineal | B | 8.44 | pKi | 3.6 | nM | Ki | J Med Chem (1995) 38: 3415-3444 [PMID:7658428] |
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] | ||||||||
ChEMBL | DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) | B | 6.3 | pKi | 500 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Alpha-1A adrenergic receptor radioligand binding (ligand: prazosin) | B | 5.91 | pIC50 | 1235 | nM | IC50 | DrugMatrix in vitro pharmacology data |
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] | ||||||||
ChEMBL | Inhibition of [3H]prazosin binding to human Alpha-1B adrenergic receptor expressed in CHO cells | B | 6.02 | pKi | 966 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
ChEMBL | Binding affinity against Alpha-1B adrenergic receptor from human clone | B | 8.14 | pKi | 7.2 | nM | Ki | J Med Chem (1995) 38: 3415-3444 [PMID:7658428] |
ChEMBL | Binding affinity against Alpha-1B adrenergic receptor from hamster clones. | B | 8.96 | pKi | 1.1 | nM | Ki | J Med Chem (1995) 38: 3415-3444 [PMID:7658428] |
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] | ||||||||
ChEMBL | DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) | B | 6.18 | pKi | 658 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Alpha-1B adrenergic receptor radioligand binding (ligand: prazosin) | B | 5.93 | pIC50 | 1188 | nM | IC50 | DrugMatrix in vitro pharmacology data |
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] | ||||||||
ChEMBL | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | B | 6.3 | pKi | 498 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Inhibition of [3H]prazosin binding to human Alpha-1D adrenergic receptor expressed in CHO cells | B | 6.54 | pKi | 289 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
ChEMBL | Binding affinity against Alpha-1D adrenergic receptor, from human clones. | B | 8.8 | pKi | 1.6 | nM | Ki | J Med Chem (1995) 38: 3415-3444 [PMID:7658428] |
ChEMBL | DRUGMATRIX: Alpha-1D adrenergic receptor radioligand binding (ligand: prazosin) | B | 5.99 | pIC50 | 1013 | nM | IC50 | DrugMatrix in vitro pharmacology data |
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] | ||||||||
ChEMBL | Binding affinity against Alpha-1D adrenergic receptor, from rat clones. | B | 7.28 | pKi | 52 | nM | Ki | J Med Chem (1995) 38: 3415-3444 [PMID:7658428] |
α2A-adrenoceptor/Alpha-2a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1867] [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
ChEMBL | Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2A adrenergic receptor | B | 8.12 | pKi | 7.5 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
ChEMBL | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2A receptor expressed in CHO cell membranes incubated for 60 mins | B | 8.5 | pKi | 3.13 | nM | Ki | J Med Chem (2020) 63: 433-439 [PMID:31834797] |
ChEMBL | Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins | B | 8.51 | pKi | 3.1 | nM | Ki | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
ChEMBL | Inhibition of [3H]- MK-912 binding against human recombinant Alpha-2A adrenergic receptor | B | 8.51 | pKi | 3.1 | nM | Ki | J Med Chem (1999) 42: 5181-5187 [PMID:10602703] |
ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 8.64 | pKi | 2.31 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | In vitro binding affinity towards alpha-2a adrenergic receptor | B | 8.85 | pKi | 1.4 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2758-2760 [PMID:15911252] |
GtoPdb | - | - | 9.2 | pKi | - | - | - |
J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470]; Mol Pharmacol (1992) 42: 1-5 [PMID:1353247]; Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]; Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877] |
ChEMBL | Binding affinity against human Alpha-2A adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand | B | 9.38 | pKi | 0.42 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 627-630 [PMID:10762040] |
ChEMBL | Displacement of [3H]MK912 from human recombinant alpha2A adrenergic receptor expressed in Sf9 cells after 60 mins | B | 8.08 | pIC50 | 8.4 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082] |
ChEMBL | DRUGMATRIX: Alpha-2A adrenergic receptor radioligand binding (ligand: MK-912) | B | 8.21 | pIC50 | 6.15 | nM | IC50 | DrugMatrix in vitro pharmacology data |
ChEMBL | Displacement of [3H]MK912 from human recombinant adrenergic alpha2A receptor expressed in Sf9 cells | B | 8.07 | pEC50 | 8.5 | nM | EC50 | J Nat Prod (2006) 69: 432-435 [PMID:16562853] |
Alpha-2a adrenergic receptor in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2350] [UniProtKB: P18871] | ||||||||
ChEMBL | Compound was evaluated for inhibition of binding of [3H]yohimbine to Alpha-2 adrenergic receptor in porcine alpha2-clone | B | 8.36 | pKi | 4.4 | nM | Ki | J Med Chem (1995) 38: 3415-3444 [PMID:7658428] |
Alpha-2a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4744] [UniProtKB: Q28838] | ||||||||
ChEMBL | Binding activity against alpha-2 adrenergic receptor from calf cerebral cortex, using [3H]clonidine as the radioligand | B | 7.31 | pKi | 49 | nM | Ki | J Med Chem (1983) 26: 1696-1701 [PMID:6139479] |
ChEMBL | Evaluated for its ability to displace [3H]clonidine from alpha-2 adrenergic receptor of calf cerebral cortex | B | 7.31 | pKi | 49 | nM | Ki | J Med Chem (1985) 28: 1756-1759 [PMID:2999400] |
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1942] [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
ChEMBL | Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin) | B | 7.54 | pKi | 28.84 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159] |
ChEMBL | DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) | B | 8.1 | pKi | 7.95 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | In vitro binding affinity towards alpha-2b adrenergic receptor | B | 8.15 | pKi | 7.1 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2758-2760 [PMID:15911252] |
ChEMBL | Inhibition of [3H]rauwolscine binding to CHO cells expressing the human Alpha-2B adrenergic receptor | B | 8.34 | pKi | 4.6 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
ChEMBL | Displacement of [125I]Clonidine from adrenergic alpha2B receptor (unknown origin) | B | 8.49 | pKi | 3.2 | nM | Ki | Bioorg Med Chem Lett (2014) 24: 576-579 [PMID:24365159] |
ChEMBL | Binding affinity against human alpha 2b-adrenergic receptor expressed stably in CHO cells using [3H]rauwolscine as radioligand | B | 8.7 | pKi | 2.01 | nM | Ki | Bioorg Med Chem Lett (2000) 10: 627-630 [PMID:10762040] |
GtoPdb | - | - | 8.9 | pKi | - | - | - |
J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470]; Mol Pharmacol (1992) 42: 1-5 [PMID:1353247]; Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]; Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877] |
ChEMBL | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2B receptor expressed in CHO cell membranes incubated for 60 mins | B | 8.94 | pKi | 1.16 | nM | Ki | J Med Chem (2020) 63: 433-439 [PMID:31834797] |
ChEMBL | DRUGMATRIX: Alpha-2B adrenergic receptor radioligand binding (ligand: Rauwolscine) | B | 7.77 | pIC50 | 17 | nM | IC50 | DrugMatrix in vitro pharmacology data |
α2B-adrenoceptor/Alpha-2b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL266] [GtoPdb: 26] [UniProtKB: P19328] | ||||||||
ChEMBL | Inhibition of [3H]- Yohimbine binding against rat kidney cortex Alpha-2B adrenergic receptor | B | 8.7 | pKi | 2 | nM | Ki | J Med Chem (1999) 42: 5181-5187 [PMID:10602703] |
α2C-adrenoceptor/Alpha-2c adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1916] [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
ChEMBL | DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) | B | 8.29 | pKi | 5.16 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | Inhibition of [3H]rauwolscine to CHO cells expressing the human Alpha-2C adrenergic receptor | B | 8.64 | pKi | 2.3 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
ChEMBL | In vitro binding affinity measured by displacement of [3H]rauwolscine from alpha-2c adrenergic receptor expressed in CHO cells in presence of phentolamine | B | 9.06 | pKi | 0.88 | nM | Ki | Bioorg Med Chem Lett (2005) 15: 2758-2760 [PMID:15911252] |
ChEMBL | Displacement of [3H]RX 821002 from human recombinant adrenergic alpha-2C receptor expressed in CHO cell membranes incubated for 60 mins | B | 9.1 | pKi | 0.8 | nM | Ki | J Med Chem (2020) 63: 433-439 [PMID:31834797] |
ChEMBL | Displacement of [3H]RX821002 from human recombinant alpha2C adrenoceptor expressed in CHO cells | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (2014) 57: 4543-4557 [PMID:24805037] |
ChEMBL | Displacement of [3H]RX-821002 from human adrenergic alpha2C receptor expressed in CHO cells | B | 9.3 | pKi | 0.5 | nM | Ki | Eur J Med Chem (2015) 92: 221-235 [PMID:25557493] |
GtoPdb | - | - | 9.5 | pKi | - | - | - |
J Pharmacol Exp Ther (1994) 271: 1558-65 [PMID:7996470]; Mol Pharmacol (1992) 42: 1-5 [PMID:1353247]; Eur J Pharmacol (1994) 252: 43-9 [PMID:7908642]; Pharmacol Res Perspect (2022) 10: e00936 [PMID:35224877] |
ChEMBL | DRUGMATRIX: Adrenergic Alpha-2C radioligand binding (ligand: [3H] MK-912) | B | 7.44 | pIC50 | 36 | nM | IC50 | DrugMatrix in vitro pharmacology data |
GtoPdb | - | - | 8.2 | pIC50 | - | - | - | Brain Res Bull (2014) 107: 89-101 [PMID:25080296] |
CYP2D6/Cytochrome P450 2D6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL289] [GtoPdb: 1329] [UniProtKB: P10635] | ||||||||
ChEMBL | DRUGMATRIX: CYP450, 2D6 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin) | B | 5.69 | pIC50 | 2031.7 | nM | IC50 | DrugMatrix in vitro pharmacology data |
DNA topoisomerase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781] [GtoPdb: 2636] [UniProtKB: P11387] | ||||||||
ChEMBL | Inhibition of human recombinant DNA topoisomerase1 | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Nat Prod (2005) 68: 848-852 [PMID:15974606] |
D2 receptor/Dopamine D2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL217] [GtoPdb: 215] [UniProtKB: P14416] | ||||||||
ChEMBL | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | B | 6.16 | pKi | 687 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Dopamine D2L radioligand binding (ligand: [3H] Spiperone) | B | 5.69 | pIC50 | 2060 | nM | IC50 | DrugMatrix in vitro pharmacology data |
D2 receptor/Dopamine D2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL339] [GtoPdb: 215] [UniProtKB: P61169] | ||||||||
ChEMBL | In vitro inhibition of specific binding of [3H]-YM 09151-2 to Dopamine receptor D2 site in rat striatal tissue. | B | 5.95 | pIC50 | 1125 | nM | IC50 | J Med Chem (2000) 43: 3653-3664 [PMID:11020279] |
D3 receptor/Dopamine D3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3138] [GtoPdb: 216] [UniProtKB: P19020] | ||||||||
ChEMBL | Tested for binding affinity against dopamine receptor D3 expressed in Sf9 cells. | B | 5.61 | pKi | 2430 | nM | Ki | J Med Chem (1993) 36: 1499-1500 [PMID:8098771] |
Dual specificity phosphatase Cdc25A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3775] [UniProtKB: P30304] | ||||||||
ChEMBL | Inhibition of His-tagged Cdc25A expressed in the Escherichia coli BL21(DE3) using p-nitrophenyl phosphate as substrate for 80 mins by spectrophotometry | B | 4.65 | pIC50 | 22300 | nM | IC50 | J Med Chem (2012) 55: 5989-6001 [PMID:22537178] |
NET/Norepinephrine transporter in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL222] [GtoPdb: 926] [UniProtKB: P23975] | ||||||||
ChEMBL | Inhibitory activity against norepinephrine (NE) uptake in rat whole brain synaptosome preparation | F | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (1996) 39: 570-581 [PMID:8558529] |
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908] | ||||||||
GtoPdb | - | - | 7.3 | pKi | - | - | - | Synapse (2000) 35: 79-95 [PMID:10611634] |
5-HT1A receptor/Serotonin 1a (5-HT1a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL273] [GtoPdb: 1] [UniProtKB: P19327] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 7.14 | pKi | 72 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT1A radioligand binding (ligand: [3H] 8-OH-DPAT) | B | 6.9 | pIC50 | 126 | nM | IC50 | DrugMatrix in vitro pharmacology data |
5-HT2A receptor/Serotonin 2a (5-HT2a) receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL322] [GtoPdb: 6] [UniProtKB: P14842] | ||||||||
ChEMBL | Binding affinity for 5-HT 2A in rat stomach fundus | B | 5.79 | pKi | 1621.81 | nM | Ki | J Med Chem (1996) 39: 2773-2780 [PMID:8709108] |
5-HT2B receptor/Serotonin 2b (5-HT2b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1833] [GtoPdb: 7] [UniProtKB: P41595] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 7.33 | pKi | 47 | nM | Ki | DrugMatrix in vitro pharmacology data |
GtoPdb | - | - | 7.9 | pKi | - | - | - |
Mol Pharmacol (1994) 46: 227-34 [PMID:8078486]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 17-24 [PMID:9459568]; Br J Pharmacol (1999) 127: 1075-82 [PMID:10455251] |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT2B radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 7.13 | pIC50 | 74 | nM | IC50 | DrugMatrix in vitro pharmacology data |
5-HT2B receptor in Rat [GtoPdb: 7] [UniProtKB: P30994] | ||||||||
GtoPdb | - | - | 7.3 | pKi | - | - | - | Mol Pharmacol (1993) 43: 419-26 [PMID:8450835] |
5-HT2C receptor/Serotonin 2c (5-HT2c) receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3006] [GtoPdb: 8] [UniProtKB: P34968] | ||||||||
ChEMBL | Binding affinity analysed towards 5-HT 2C in rat stomach fundus | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (1996) 39: 2773-2780 [PMID:8709108] |
5-HT6 receptor/Serotonin 6 (5-HT6) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3371] [GtoPdb: 11] [UniProtKB: P50406] | ||||||||
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 6.11 | pKi | 784 | nM | Ki | DrugMatrix in vitro pharmacology data |
ChEMBL | DRUGMATRIX: Serotonin (5-Hydroxytryptamine) 5-HT6 radioligand binding (ligand: [3H] Lysergic acid diethylamide) | B | 5.77 | pIC50 | 1689 | nM | IC50 | DrugMatrix in vitro pharmacology data |
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
ChEMBL | Inhibition of [3H]nitrendipine binding to membrane homogenates of rat cardiac muscle. | B | 7.35 | pKi | 45 | nM | Ki | J Med Chem (1995) 38: 3681-3716 [PMID:7562902] |
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
GtoPdb | - | - | 7.6 | pKi | - | - | - |
Synapse (2000) 35: 79-95 [PMID:10611634]; Proc Natl Acad Sci USA (1992) 89: 3630-4 [PMID:1565658] |
5-HT1B receptor in Mouse [GtoPdb: 2] [UniProtKB: P28334] | ||||||||
GtoPdb | - | - | 8.3 | pKi | - | - | - | Proc Natl Acad Sci USA (1992) 89: 3020-4 [PMID:1557407] |
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
GtoPdb | - | - | 7.7 | pKi | - | - | - |
Synapse (2000) 35: 79-95 [PMID:10611634]; Proc Natl Acad Sci USA (1992) 89: 3630-4 [PMID:1565658]; Mol Pharmacol (1996) 50: 1567-80 [PMID:8967979]; Mol Pharmacol (1991) 40: 143-8 [PMID:1652050] |
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566] | ||||||||
GtoPdb | - | - | 5.9 | pKi | - | - | - | Proc Natl Acad Sci USA (1993) 90: 408-12 [PMID:8380639] |
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939] | ||||||||
GtoPdb | - | - | 7 | pKi | - | - | - | Proc Natl Acad Sci USA (1993) 90: 408-12 [PMID:8380639] |
5-HT1F receptor in Rat [GtoPdb: 5] [UniProtKB: P30940] | ||||||||
GtoPdb | - | - | 6.2 | pIC50 | - | - | - | Proc Natl Acad Sci USA (1993) 90: 2184-8 [PMID:8384716] |
5-HT5A receptor in Human [GtoPdb: 10] [UniProtKB: P47898] | ||||||||
GtoPdb | - | - | 5.3 | pKi | - | - | - | FEBS Lett (1994) 355: 242-6 [PMID:7988681] |
5-HT5A receptor in Mouse [GtoPdb: 10] [UniProtKB: P30966] | ||||||||
GtoPdb | - | - | 6 | pKi | - | - | - |
Mol Pharmacol (1993) 43: 313-9 [PMID:8450829]; FEBS Lett (1995) 377: 451-6 [PMID:8549774] |
5-HT7 receptor in Human [GtoPdb: 12] [UniProtKB: P34969] | ||||||||
GtoPdb | - | - | 5.6 | pKi | - | - | - | J Biol Chem (1993) 268: 23422-6 [PMID:8226867] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]