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ChEMBL ligand: CHEMBL40157 (CGP-35348) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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GABAB2/GABAB1/GABA B receptor in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111474] [GtoPdb: 241, 240] [UniProtKB: O88871, Q9Z0U4] | ||||||||
GtoPdb | - | - | 4.8 | pIC50 | - | - | - |
Nature (1997) 386: 239-46 [PMID:9069281]; J Med Chem (1995) 38: 3313-31 [PMID:7650685] |
ChEMBL | In vitro displacement of [3H]GABA from Gamma-aminobutyric acid type B receptor sites in rat brain membranes | B | 5.6 | pIC50 | 2500 | nM | IC50 | Bioorg Med Chem Lett (1993) 3: 515-518 |
GABAB1/GABA-B receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2753] [GtoPdb: 240] [UniProtKB: Q9Z0U4] | ||||||||
ChEMBL | Inhibition of binding of [3H]CGP-27492 to gamma-aminobutyric acid type B receptor of rat cortex. | B | 4.57 | pIC50 | 27000 | nM | IC50 | J Med Chem (1995) 38: 3313-3331 [PMID:7650685] |
GtoPdb | - | - | 4.8 | pIC50 | - | - | - |
Nature (1997) 386: 239-46 [PMID:9069281]; J Med Chem (1995) 38: 3313-31 [PMID:7650685] |
GABAB receptor in Human [GtoPdb: 242] | ||||||||
GtoPdb | - | - | 4.4 | pKi | - | - | - | Br J Pharmacol (2000) 131: 1050-4 [PMID:11082110] |
GABAB receptor in Rat [GtoPdb: 242] | ||||||||
GtoPdb | - | - | 5.4 | pIC50 | - | - | - | Pharmacol Rev (2002) 54: 247-64 [PMID:12037141] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]