Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL312040 (Acscn-9624, Arc 1g2, BA-20684, Ciba 20-684ba, Etobedolum, Etonitazene, Etonitazine, IDS-NE-006, NIH 7607, NIH-7607) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
δ receptor in Human [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
GtoPdb | - | - | 6.7 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
ChEMBL | Opioid receptor delta 1 apparent binding constant from rat brain membranes using [3H]DADLE binding assay | B | 6 | pKi | >1000 | nM | Ki | J Med Chem (1990) 33: 2456-2464 [PMID:2167979] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]-Diprenorphine from human mu opioid receptor expressed in HEK293-TSA cell membranes after 4 hrs by scintillation counting method | B | 9.7 | pKi | 0.2 | nM | Ki | J Med Chem (2018) 61: 1646-1663 [PMID:29400965] |
GtoPdb | - | - | 9.7 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
GtoPdb | Potency determined as inhibition of cAMP accumulation in a Gi-cAMP assay | - | 10.52 | pEC50 | 0.03 | nM | EC50 | Psychopharmacology (Berl) (2023) 240: 2573-2584 [PMID:37658878] |
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
GtoPdb | Binding affinity determined in radioligand displacement assay using rat brain and [3H]DAMGO as tracer | - | 8.18 | pKi | 6.6 | nM | Ki | Psychopharmacology (Berl) (2023) 240: 2573-2584 [PMID:37658878] |
ChEMBL | Inhibition of [3H]DAGO binding to rat brain membrane Opioid receptor mu 1 | B | 9.3 | pKi | 0.5 | nM | Ki | J Med Chem (1990) 33: 2456-2464 [PMID:2167979] |
Mu-type opioid receptor in Rhesus macaque (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5799] [UniProtKB: Q9MYW9] | ||||||||
ChEMBL | Binding affinity to mu opioid receptor in rhesus monkey brain membrane in absence of Na+ ions | B | 10.7 | pKi | 0.02 | nM | Ki | Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056] |
ChEMBL | Binding affinity to mu opioid receptor in rhesus monkey brain membrane in presence of Na+ ions | B | 11 | pKi | 0.01 | nM | Ki | Eur J Med Chem (2008) 43: 2307-2315 [PMID:18403056] |
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
GtoPdb | - | - | 6.9 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]