BX 667 [Ligand Id: 1767] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2172275 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| P2Y12 receptor/Purinergic receptor P2Y12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2001] [GtoPdb: 328] [UniProtKB: Q9H244] | ||||||||
| ChEMBL | Displacement of [33P]2-MeS-ADP from human recombinant P2Y12 receptor expressed in CHO cell membranes by scintillation counting method | B | 7.07 | pKi | 86 | nM | Ki | J Med Chem (2012) 55: 8615-8629 [PMID:22984835] |
| ChEMBL | Antagonist activity at P2Y12 receptor in human washed platelets assessed as inhibition of ADP-induced platelet aggregation measured for 5 mins by light transmission analysis | B | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2739-2754 [PMID:27133596] |
| GtoPdb | - | - | 7 | pIC50 | - | - | - | Thromb Res (2008) 122: 533-40 [PMID:18539312] |
| ChEMBL | Displacement of [3H]-2-Mes-ADP from human P2Y12 receptor | B | 7.54 | pIC50 | 29 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 2739-2754 [PMID:27133596] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
