butaprost (free acid form) [Ligand Id: 1892] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1628262 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| ChEMBL | Binding affinity to EP1 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| GtoPdb | - | - | 7 | pKi | - | - | - |
Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; Mol Pharmacol (1999) 56: 545-51 [PMID:10462542] |
| ChEMBL | Binding affinity to EP2 receptor (unknown origin) by competitive binding assay | B | 7.14 | pKi | 73 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| ChEMBL | Agonist activity at EP2 receptor (unknown origin) by functional assay | B | 7.49 | pEC50 | 32 | nM | EC50 | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP2 receptor in Rat [GtoPdb: 341] [UniProtKB: Q62928] | ||||||||
| GtoPdb | - | - | 7.2 | pKi | - | - | - | Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| ChEMBL | Binding affinity to EP3 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| GtoPdb | - | - | 5.78 | pKi | 1643 | nM | Ki | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| EP3 receptor in Rat [GtoPdb: 342] [UniProtKB: P34980] | ||||||||
| GtoPdb | - | - | 4.93 | pKi | 11800 | nM | Ki | Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| GtoPdb | - | - | 4.7 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Binding affinity to EP4 receptor (unknown origin) | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| EP4 receptor in Rat [GtoPdb: 343] [UniProtKB: P43114] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | Eur J Pharmacol (1997) 340: 227-41 [PMID:9537820] |
| IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| GtoPdb | - | - | 4.3 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Binding affinity to prostanoid IP receptor (unknown origin) | B | 6.06 | pKi | 870 | nM | Ki | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| ChEMBL | Agonist activity at prostanoid IP receptor (unknown origin) by functional assay | B | 7.6 | pIC50 | 25 | nM | IC50 | J Med Chem (2014) 57: 4454-4465 [PMID:24279689] |
| DP1 receptor in Human [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| GtoPdb | - | - | 4.9 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| TP receptor in Human [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| GtoPdb | - | - | 4.7 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
