TM30089 [Ligand Id: 1905] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1643768 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP2 receptor/G protein-coupled receptor 44 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5071] [GtoPdb: 339] [UniProtKB: Q9Y5Y4] | ||||||||
| ChEMBL | Binding affinity to human recombinant CRTH2 receptor by cell based radioligand equilibrium competition assay | B | 8.22 | pKi | 6 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375] |
| GtoPdb | - | - | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (2005) 48: 897-900 [PMID:15715457] |
| ChEMBL | Inhibition of CRTH2 | B | 9.22 | pKi | 0.6 | nM | Ki | J Med Chem (2012) 55: 2915-2931 [PMID:22224640] |
| ChEMBL | Inhibition of CRTH2 | B | 8.44 | pIC50 | 3.6 | nM | IC50 | J Med Chem (2012) 55: 2915-2931 [PMID:22224640] |
| GtoPdb | - | - | 8.92 | pIC50 | 1.2 | nM | IC50 |
J Med Chem (2005) 48: 897-900 [PMID:15715457]; Allergy (2007) 62: 1401-9 [PMID:17714552] |
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| ChEMBL | Binding affinity to prostanoid DP1 receptor | B | 6.19 | pKi | 653 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375] |
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| ChEMBL | Inhibition of TP receptor | B | 5 | pKi | >10000 | nM | Ki | J Med Chem (2012) 55: 2915-2931 [PMID:22224640] |
| ChEMBL | Binding affinity to thromboxane receptor | B | 5.86 | pKi | 1394 | nM | Ki | Bioorg Med Chem Lett (2011) 21: 288-293 [PMID:21106375] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
