daltroban [Ligand Id: 1986] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL71685 (BM 13.505, BM-13505, BM13505, Daltroban, SK&F 96148, SKF-96148, SKF96148) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| ChEMBL | Compound was tested for its binding affinity at Thromboxane A2/ Prostaglandin H2 receptor by measuring its ability to displace [3H]U-46619 from guinea pig platelets | B | 7.2 | pKi | 63 | nM | Ki | J Med Chem (1992) 35: 3402-3413 [PMID:1388208] |
| GtoPdb | - | - | 7.7 | pKi | - | - | - | Jpn J Pharmacol (1992) 59: 357-64 [PMID:1434130] |
| ChEMBL | In vitro thromboxane A2 antagonistic activity on aggregation of rabbit platelets induced by U-46,619 (4 uM) | F | 6.34 | pIC50 | 460 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 401-406 [PMID:10091692] |
| ChEMBL | In vitro thromboxane-A2 receptor binding affinity to displace by 50% [3H]-SQ 29548 binding from washed human platelets | B | 6.82 | pIC50 | 150 | nM | IC50 | J Med Chem (1994) 37: 3588-3604 [PMID:7932586] |
| TP receptor/Thromboxane A2 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3156] [GtoPdb: 346] [UniProtKB: P34978] | ||||||||
| ChEMBL | In vitro thromboxane A2 antagonistic activity on U-46619 (0.1 uM) induced contraction of rat aorta | F | 7.43 | pIC50 | 37.1 | nM | IC50 | Bioorg Med Chem Lett (1999) 9: 401-406 [PMID:10091692] |
| CYP5A1/Thromboxane-A synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4028] [GtoPdb: 1353] [UniProtKB: P49430] | ||||||||
| ChEMBL | In vitro inhibition of thromboxane-A2 synthase in rat whole blood during clotting at 37 degrees Centigrade | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (1994) 37: 3588-3604 [PMID:7932586] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
