diltiazem [Ligand Id: 2298] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL23 (Cardizem, Dilt-CD, Diltiazem, Diltiazem extended release, Diltzac, Ditiaz, Surazem, Tiamate, Tiazac) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP3A4/Cytochrome P450 3A4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL340] [GtoPdb: 1337] [UniProtKB: P08684] | ||||||||
| ChEMBL | DRUGMATRIX: CYP450, 3A4 enzyme inhibition (substrate: 7-Benzyloxy-4-(trifluoromethyl)-coumarin) | B | 5.74 | pIC50 | 1836.6 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibitory concentration against potassium channel HERG | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
| ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
| ChEMBL | Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state | F | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
| ChEMBL | Inhibition of human ERG in MCF7 cells | B | 4.76 | pIC50 | 17378.01 | nM | IC50 | Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341] |
| ChEMBL | K+ channel blocking activity in human embryonic kidney cells expressing HERG Kv11.1 | F | 4.76 | pIC50 | 17300 | nM | IC50 | J Med Chem (2002) 45: 3844-3853 [PMID:12190308] |
| ChEMBL | Inhibition of hERG K channel | F | 4.76 | pIC50 | 17300 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 0.1 uM) in MDR1-expressing LLC-PK1 cells | F | 4.11 | pIC50 | 77700 | nM | IC50 | Eur J Pharm Sci (2002) 16: 159-165 [PMID:12128170] |
| ChEMBL | Inhibition of P-glycoprotein by Hoechst assay | B | 4.21 | pIC50 | 61659.5 | nM | IC50 | Bioorg Med Chem (2007) 15: 7470-7479 [PMID:17890094] |
| ChEMBL | Inhibition of P-glycoprotein-mediated multidrug resistance in adriamycin-resistant human A2780/ADR cells by calcein AM assay | B | 4.31 | pIC50 | 49000 | nM | IC50 | Bioorg Med Chem (2009) 17: 2524-2535 [PMID:19250834] |
| ChEMBL | Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay | B | 4.37 | pIC50 | 42657.95 | nM | IC50 | Bioorg Med Chem (2007) 15: 7470-7479 [PMID:17890094] |
| ChEMBL | Inhibition of P-gp in human adriamycin-resistant A2780 cells by Hoechst 33342 assay | B | 4.37 | pIC50 | 42657.95 | nM | IC50 | Bioorg Med Chem (2008) 16: 8224-8236 [PMID:18678495] |
| Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] | ||||||||
| ChEMBL | Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells by confocal microscopy | B | 4.91 | pIC50 | 12400 | nM | IC50 | J Med Chem (2008) 51: 5932-5942 [PMID:18788725] |
| Voltage-dependent L-type calcium channel subunit alpha-1C in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366456] [UniProtKB: O35505] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 4.13 | pIC50 | 74000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 4.52 | pIC50 | 30000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in guinea pig ventricular myocytes | F | 6.2 | pIC50 | 630 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit | F | 4.36 | pIC50 | 44000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| Cav1.2 in Ferret [GtoPdb: 529] | ||||||||
| GtoPdb | - | - | 6.3 | pIC50 | - | - | - | J Pharmacol Exp Ther (1984) 228: 245-51 [PMID:6694106] |
| Voltage-gated L-type calcium channel alpha-1C subunit in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2830] [UniProtKB: P15381] | ||||||||
| ChEMBL | Inhibition of [3H]nitrendipine binding to calcium channels in rabbit cardiac muscle | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (1988) 31: 2221-2227 [PMID:3184128] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Calcium antagonistic activity by measuring [3H]nitrendipine displacement from rat heart L-type [Ca2+] channel | F | 6.55 | pKi | 280 | nM | Ki | J Med Chem (1995) 38: 4393-4410 [PMID:7473567] |
| ChEMBL | Binding of [3H]nitrendipine to calcium channel in rat heart membranes was determined | B | 6 | pIC50 | >1000 | nM | IC50 | Bioorg Med Chem Lett (1994) 4: 351-354 |
| ChEMBL | In vitro inhibition of K+ induced contractions of the isolated rat aorta. | F | 7 | pIC50 | 100 | nM | IC50 | J Med Chem (1998) 41: 4309-4316 [PMID:9784106] |
| ChEMBL | Ability to inhibit [3H]nitrendipine binding to the L-type calcium channel receptor(CCR) in rat heart homogenate. | B | 7.27 | pIC50 | 54 | nM | IC50 | J Med Chem (1996) 39: 2922-2938 [PMID:8709127] |
| Cav1.3 in Mouse [GtoPdb: 530] [UniProtKB: Q99246] | ||||||||
| GtoPdb | - | - | 3.5 | pIC50 | - | - | - | Eur J Pharmacol (2007) 573: 39-48 [PMID:17651721] |
| Cav1.3/Voltage-gated L-type calcium channel alpha-1D subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4132] [GtoPdb: 530] [UniProtKB: P27732] | ||||||||
| ChEMBL | Inhibition of [3H]nitrendipine binding to L-type [Ca2+] channel in rat cortex homogenate, activity expressed as pIC50 | B | 7.34 | pIC50 | 45.71 | nM | IC50 | J Med Chem (1997) 40: 125-131 [PMID:9016337] |
| Cav1.1/Voltage-gated L-type calcium channel alpha-1S subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3805] [GtoPdb: 528] [UniProtKB: Q13698] | ||||||||
| ChEMBL | Displacement of [3H]diltiazem from L-type calcium channel of guinea pig striated muscle | B | 6.42 | pKi | 380 | nM | Ki | Bioorg Med Chem Lett (1993) 3: 2797-2800 |
| Cav1.1 in Rabbit [GtoPdb: 528] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | 63096 | nM | IC50 | J Pharmacol Exp Ther (1986) 236: 403-7 [PMID:2418195] |
| 5-HT3A in Human [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 4.68 | pIC50 | 21000 | nM | IC50 | Mol Pharmacol (2011) 80: 183-90 [PMID:21505038] |
| 5-HT3A in Mouse [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 5.26 | pIC50 | 5500 | nM | IC50 |
J Physiol (Lond.) (1999) 519 Pt 3: 713-22 [PMID:10457085]; Biol Pharm Bull (2009) 32: 861-7 [PMID:19420755] |
| Cav1.4 in Mouse [GtoPdb: 531] [UniProtKB: Q9JIS7] | ||||||||
| GtoPdb | - | - | 4 | pIC50 | - | - | - | Invest Ophthalmol Vis Sci (2004) 45: 708-13 [PMID:14744918] |
| Kv1.1 in Mouse [GtoPdb: 538] [UniProtKB: P16388] | ||||||||
| GtoPdb | - | - | 3.8 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142] | ||||||||
| GtoPdb | - | - | 3.7 | pKd | 187000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| GtoPdb | - | - | 3.9 | pKd | 115000 | nM | Kd | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
| Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] | ||||||||
| GtoPdb | - | - | 4.2 | pIC50 | - | - | - | J Biol Chem (1998) 273: 5851-7 [PMID:9488722] |
| Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] | ||||||||
| GtoPdb | - | - | 4 | pIC50 | - | - | - | Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
