chlorzoxazone [Ligand Id: 2322] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL1371 (Chlorzoxazone, NSC-26189, Paraflex, Parafon, Parafon Forte, Parafon-Forte, Parafon forte dsc, Strifon, Strifon forte dsc) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Neuronal NOS/Nitric-oxide synthase, brain in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3568] [GtoPdb: 1251] [UniProtKB: P29475] | ||||||||
| ChEMBL | Inhibitory activity against Neuronal nitric oxide synthase | B | 4.3 | pIC50 | 50000 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2887-2892 |
| Neuronal NOS/Nitric-oxide synthase, brain in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3048] [GtoPdb: 1251] [UniProtKB: P29476] | ||||||||
| ChEMBL | DRUGMATRIX: Nitric Oxide Synthase, Neuronal (nNOS) radioligand binding (ligand: [3H]L-Arginine) | B | 5.55 | pIC50 | 2794 | nM | IC50 | DrugMatrix in vitro pharmacology data |
| Endothelial NOS/Nitric-oxide synthase, endothelial in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4803] [GtoPdb: 1249] [UniProtKB: P29474] | ||||||||
| ChEMBL | Inhibitory activity against Endothelial nitric oxide synthase | B | 5.06 | pIC50 | 8700 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2887-2892 |
| Inducible NOS/Nitric oxide synthase, inducible in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4481] [GtoPdb: 1250] [UniProtKB: P35228] | ||||||||
| ChEMBL | Inhibitory activity against Inducible nitric oxide synthase | B | 4.85 | pIC50 | 14100 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2887-2892 |
| KCa2.2 in Rat [GtoPdb: 382] [UniProtKB: P70604] | ||||||||
| GtoPdb | - | - | 4.1 | pEC50 | - | - | - |
Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246]; J Pharmacol Exp Ther (2001) 296: 683-9 [PMID:11181893] |
| KCa3.1 in Human [GtoPdb: 384] [UniProtKB: O15554] | ||||||||
| GtoPdb | - | - | 4 | pEC50 | 100000 | nM | EC50 | Am J Physiol, Cell Physiol (2000) 278: C570-81 [PMID:10712246] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
