ChEMBL ligand: CHEMBL284348 (Ampyra, Ampyra Extended Release, Dalfampridine, EL-970, Fampridine, Fampridine (4-aminopyridine), Fampyra, Neurelan, NSC-15041)
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470] There should be some charts here, you may need to enable JavaScript!
Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142] There should be some charts here, you may need to enable JavaScript!
Kv1.4 in Rat [GtoPdb: 541] [UniProtKB: P15385] There should be some charts here, you may need to enable JavaScript!
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] There should be some charts here, you may need to enable JavaScript!
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2] There should be some charts here, you may need to enable JavaScript!
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322] There should be some charts here, you may need to enable JavaScript!
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387] There should be some charts here, you may need to enable JavaScript!
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953] There should be some charts here, you may need to enable JavaScript!
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388] There should be some charts here, you may need to enable JavaScript!
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462] There should be some charts here, you may need to enable JavaScript!
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956] There should be some charts here, you may need to enable JavaScript!
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2] Kv4.1 in Mouse [GtoPdb: 552] [UniProtKB: Q03719] There should be some charts here, you may need to enable JavaScript!
Kv4.2 in Mouse [GtoPdb: 553] [UniProtKB: Q9Z0V2] There should be some charts here, you may need to enable JavaScript!
Kv4.3 in Mouse [GtoPdb: 554] [UniProtKB: Q9Z0V1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Kv1.1/Voltage-gated potassium channel subunit Kv1.1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2309] [GtoPdb: 538] [UniProtKB: Q09470]
ChEMBL	Inhibition of Kv1.1 (unknown origin)	B	4.05	pIC50	89000	nM	IC50	J Med Chem (2017) 60: 2245-2256 [PMID:28225274]
Kv1.2 in Rat [GtoPdb: 539] [UniProtKB: P63142]
GtoPdb	-	-	3.2	pKd	590000	nM	Kd	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv1.4 in Rat [GtoPdb: 541] [UniProtKB: P15385]
GtoPdb	-	-	1.9	pIC50	12500000	nM	IC50	EMBO J (1989) 8: 3235-44 [PMID:2555158]
Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460]
GtoPdb	-	-	3.6	pKd	270000	nM	Kd	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv1.7 in Mouse [GtoPdb: 544] [UniProtKB: Q17ST2]
GtoPdb	-	-	3.8	pKd	-	-	-	J Gen Physiol (2006) 128: 133-45 [PMID:16801386]
GtoPdb	-	-	3.6	pIC50	245000	nM	IC50	J Biol Chem (1998) 273: 5851-7 [PMID:9488722]
Kv1.8 in Human [GtoPdb: 545] [UniProtKB: Q16322]
GtoPdb	-	-	2.8	pIC50	1580000	nM	IC50	Am J Physiol Renal Physiol (2000) 278: F1013-21 [PMID:10836990]
Kv2.1 in Rat [GtoPdb: 546] [UniProtKB: P15387]
GtoPdb	-	-	3.3	pIC50	500000	nM	IC50	J Gen Physiol (1993) 102: 797-816 [PMID:8301258]
Kv2.2 in Human [GtoPdb: 547] [UniProtKB: Q92953]
GtoPdb	-	-	2.8	pIC50	1500000	nM	IC50	Am J Physiol (1998) 274: G901-11 [PMID:9612272]
Kv3.1 in Mouse [GtoPdb: 548] [UniProtKB: P15388]
GtoPdb	-	-	4.5	pIC50	29000	nM	IC50	Mol Pharmacol (1994) 45: 1227-34 [PMID:7517498]
Kv3.2 in Rat [GtoPdb: 549] [UniProtKB: P22462]
GtoPdb	-	-	4.6	pIC50	24000	nM	IC50	J Physiol (Lond.) (2002) 538: 405-19 [PMID:11790809]
Kv3.3 in Rat [GtoPdb: 550] [UniProtKB: Q01956]
GtoPdb	-	-	2.9	pIC50	-	-	-	Proc Biol Sci (1992) 248: 9-18 [PMID:1381835]
Kv4.1 in Human [GtoPdb: 552] [UniProtKB: Q9NSA2]
GtoPdb	-	-	2	pIC50	-	-	-	Genomics (2000) 64: 144-54 [PMID:10729221]
Kv4.1 in Mouse [GtoPdb: 552] [UniProtKB: Q03719]
GtoPdb	-	-	2	pIC50	-	-	-	Proc Natl Acad Sci USA (2002) 99: 1035-40 [PMID:11805342]
Kv4.2 in Mouse [GtoPdb: 553] [UniProtKB: Q9Z0V2]
GtoPdb	-	-	2.3	pIC50	-	-	-	Mol Pharmacol (2006) 69: 718-26 [PMID:16317109]
Kv4.3 in Mouse [GtoPdb: 554] [UniProtKB: Q9Z0V1]
GtoPdb	-	-	2.4	pIC50	-	-	-	Br J Pharmacol (2006) 149: 676-86 [PMID:17016508]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]