clofilium [Ligand Id: 2507] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL9484 (Clofilium cation, Clofilium ion) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Inhibitory concentration against IKr potassium channel | B | 6.82 | pIC50 | 150 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906] |
| ChEMBL | Inhibition of human ERG | B | 7.9 | pIC50 | 12.59 | nM | IC50 | Eur J Med Chem (2011) 46: 618-630 [PMID:21185626] |
| K2P5.1 in Mouse [GtoPdb: 517] | ||||||||
| GtoPdb | - | - | 4.6 | pIC50 | - | - | - | J Biol Chem (2001) 276: 43166-74 [PMID:11560934] |
| Kv1.5 in Human [GtoPdb: 542] [UniProtKB: P22460] | ||||||||
| GtoPdb | - | - | 6.9 | pIC50 | - | - | - | Mol Pharmacol (1995) 47: 198-205 [PMID:7838129] |
| Kv10.1 in Human [GtoPdb: 570] [UniProtKB: O95259] | ||||||||
| GtoPdb | - | - | 6.6 | pIC50 | - | - | - | Br J Pharmacol (2003) 138: 161-71 [PMID:12522086] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
