mibefradil [Ligand Id: 2522] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL45816 (Mibefradil, Posicor, Posicor 100, Posicor 50) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Cav2.2/Cacna1b/Cacnb3 in Rat (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL4296086] [GtoPdb: 533] [UniProtKB: P54287, Q02294] | ||||||||
| ChEMBL | Inhibition of rat Cav2.2-alpha1beta/beta3 expressed in HEK293 cells assessed as decrease in calcium mobilization response to KCl after 1 hr by Fluo-4-AM dye-based FLIPR assay | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Orai1/Calcium release-activated calcium channel protein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2384891] [GtoPdb: 2964] [UniProtKB: Q96D31] | ||||||||
| ChEMBL | Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction in BAPTA-induced Ca2+ depletion-stimulated SOCE activity preincubated for 15 mins followed by BAPTA addition in presence of extracellular Ca2+ by PBX-based FLIPR assay | B | 4 | pIC50 | >100000 | nM | IC50 | Bioorg Med Chem (2017) 25: 440-449 [PMID:27856238] |
| ChEMBL | Inhibition of Orai1-mediated store operated Ca2+ entry in human MDA-MB-231 cells assessed as reduction of SERCA inhibition-induced ER release preincubated for 15 mins followed by CPA addition by PBX-based FLIPR assay | B | 4.28 | pIC50 | 52100 | nM | IC50 | Bioorg Med Chem (2017) 25: 440-449 [PMID:27856238] |
| Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] | ||||||||
| ChEMBL | Displacement of [3H]dofetilide from hERG expressed in HEK293 cells by SPA | B | 6.45 | pKi | 353 | nM | Ki | J Med Chem (2007) 50: 2931-2941 [PMID:17536794] |
| ChEMBL | Binding affinity at hERG expressed in HEK293 cells by fluorescence polarization assay | B | 6.72 | pKi | 190 | nM | Ki | J Med Chem (2007) 50: 2931-2941 [PMID:17536794] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by IONWORKS assay | B | 5.48 | pIC50 | 3300 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 119-124 [PMID:23200256] |
| ChEMBL | Inhibition of hERG K channel | F | 5.74 | pIC50 | 1800 | nM | IC50 | Cardiovasc Res (2011) 91: 53-61 [PMID:21300721] |
| ChEMBL | Inhibition of human Potassium channel HERG expressed in mammalian cells | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512] |
| ChEMBL | Inhibitory concentration against potassium channel HERG | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273] |
| ChEMBL | Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342] |
| ChEMBL | Inhibition of human ERG in MCF7 cells | B | 5.84 | pIC50 | 1445.44 | nM | IC50 | Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341] |
| ChEMBL | Inhibition of human voltage-gated potassium channel subunit Kv11.1 (ERG K+ channel) in open state | F | 5.84 | pIC50 | 1445.44 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 1737-1741 [PMID:15745831] |
| ChEMBL | K+ channel blocking activity in COS-7 African green monkey kidney derived cells expressing HERG Kv11.1 | F | 5.84 | pIC50 | 1430 | nM | IC50 | J Med Chem (2002) 45: 3844-3853 [PMID:12190308] |
| ChEMBL | Inhibition of human ERG | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2705-2708 [PMID:20382529] |
| ChEMBL | Inhibitory concentration against IKr potassium channel | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906] |
| ChEMBL | Inhibition of human hERG | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 215-219 [PMID:21126876] |
| ChEMBL | Inhibition of human ERG | B | 5.85 | pIC50 | 1400 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1887-1890 [PMID:23395659] |
| ChEMBL | Inhibition of human ERG by whole-cell patch clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2019) 29: 1168-1172 [PMID:30928197] |
| ChEMBL | Inhibition of human ERG by patch clamp assay | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 5910-5915 [PMID:21843937] |
| ChEMBL | Inhibition of human ERG expressed in HEK cells by patch clamp assay | B | 5.89 | pIC50 | 1300 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3941-3946 [PMID:26231163] |
| ChEMBL | Inhibition of human ERG | B | 6.09 | pIC50 | 806 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
| ChEMBL | Inhibition of human ERG | B | 6.24 | pIC50 | 580 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] | ||||||||
| ChEMBL | Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | F | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells | F | 5.74 | pIC50 | 1800 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells | F | 5.8 | pIC50 | 1600 | nM | IC50 | Drug Metab Dispos (2000) 28: 895-898 [PMID:10901697] |
| ChEMBL | Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC | F | 5.82 | pIC50 | 1500 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) (Digoxin: 5 uM) in Caco-2 cells | F | 5.92 | pIC50 | 1200 | nM | IC50 | Mol Pharmacol (2002) 61: 964-973 [PMID:11961113] |
| P-glycoprotein 1 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3467] [UniProtKB: P06795] | ||||||||
| ChEMBL | Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells | F | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ABCB1/P-glycoprotein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2573] [GtoPdb: 768] [UniProtKB: P21447] | ||||||||
| ChEMBL | Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay | F | 5.13 | pIC50 | 7400 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| ChEMBL | TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells | F | 5.13 | pIC50 | 7400 | nM | IC50 | J Med Chem (2003) 46: 1716-1725 [PMID:12699389] |
| Plasmodium yoelii yoelii (target type: ORGANISM) [ChEMBL: CHEMBL612328] | ||||||||
| ChEMBL | Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs | F | 9.06 | pIC50 | 0.87 | nM | IC50 | Antimicrob Agents Chemother (2008) 52: 1215-1220 [PMID:18212104] |
| ChEMBL | Antimalarial activity against liver stages of Plasmodium yoelii yoelii | F | 9.06 | pIC50 | 0.87 | nM | IC50 | J Med Chem (2012) 55: 995-1012 [PMID:22122518] |
| Nav1.2/Sodium channel protein type II alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3399] [GtoPdb: 579] [UniProtKB: P04775] | ||||||||
| ChEMBL | Inhibition of rat brain Nav1.2 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Nav1.4/Sodium channel protein type IV alpha subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3509] [GtoPdb: 581] [UniProtKB: P15390] | ||||||||
| ChEMBL | Inhibition of rat skeletal muscle Nav1.4 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Nav1.7/Sodium channel protein type IX alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4296] [GtoPdb: 584] [UniProtKB: Q15858] | ||||||||
| ChEMBL | Inhibition of human Nav1.7 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Nav1.5/Sodium channel protein type V alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1980] [GtoPdb: 582] [UniProtKB: Q14524] | ||||||||
| ChEMBL | Inhibition of human heart Nav1.5 expressed in HEK293 cells by whole cell voltage clamp method | B | 6.3 | pIC50 | 500 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] | ||||||||
| GtoPdb | - | - | 4.9 | pIC50 | - | - | - | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Inhibition of Cav1.2 (unknown origin) | B | 6.6 | pIC50 | 250 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| ChEMBL | Inhibition of recombinant Cav1.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR assay | B | 6.69 | pIC50 | 202 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3941-3946 [PMID:26231163] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Inhibition of Cav1.2 calcium current measured using FLIPR in rat aortic A7r5 cells | F | 5.96 | pIC50 | 1100 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
| Cav2.2/Voltage-gated N-type calcium channel alpha-1B subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4478] [GtoPdb: 533] [UniProtKB: Q00975] | ||||||||
| ChEMBL | Inhibition of N-type calcium channel Alpha-1B | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2705-2708 [PMID:20382529] |
| ChEMBL | Antagonist activity against L-type calcium channel subunit alpha-1C assessed as inactivation of channel current by cell based patch clamp assay | F | 6.38 | pIC50 | 416 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6375-6378 [PMID:20934333] |
| Cav3.1/Voltage-gated T-type calcium channel alpha-1G subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4641] [GtoPdb: 535] [UniProtKB: O43497] | ||||||||
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 with alpha-1G subunit by patch clamp assay | B | 5.84 | pIC50 | 1430 | nM | IC50 | Bioorg Med Chem (2007) 15: 365-373 [PMID:17035033] |
| ChEMBL | Inhibition of T-type [Ca2+] channel (alpha1G) expressed in HEK293 cells | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2005) 15: 283-286 [PMID:15603940] |
| ChEMBL | Ability to block calcium channel T type 3.1v expressed in HEK293 cells by whole cell patch clamp method | F | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 5244-5248 [PMID:16876404] |
| ChEMBL | Inhibition of T type calcium channel Cav3.1 (unknown origin) expressed in HEK293T cells by patch clamp method relative to control | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2016) 26: 1073-1079 [PMID:26739776] |
| ChEMBL | Inhibition of T type calcium channel subunit alpha-1G expressed in HEK293 cells assessed as effect on T-type calcium currents by patch clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2007) 15: 1409-1419 [PMID:17150365] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 alpha-1G subunit expressed in HEK293 cells assessed as calcium current by patch-clamp assay | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 5740-5743 [PMID:17869104] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit by whole-cell patch clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 471-475 [PMID:17064894] |
| ChEMBL | Inhibition of T-type calcium channel Cav3.1 expressed in HEK293 cells co-expressing alpha1G subunit and Kir2.1 potassium channel by patch-clamp assay | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2007) 17: 476-481 [PMID:17092715] |
| ChEMBL | Antagonist activity at T type calcium channel alpha1G expressed in HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp method | F | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 4424-4427 [PMID:18625556] |
| ChEMBL | Inhibition of T-type calcium channel alpha1G expressed in human HEK293 cells assessed as inhibition of peak currents by whole-cell patch-clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 2705-2708 [PMID:20382529] |
| ChEMBL | Inhibition of human Cav3.1 expressed in tsA-201 cells by patch clamp electrophysiology | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2020) 28: 115491-115491 [PMID:32327350] |
| ChEMBL | Inhibition of T-type alpha1G calcium channel expressed in HEK293 cells assessed as Kcl-induced depolarization | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 215-219 [PMID:21126876] |
| ChEMBL | Inhibition of T-type alpha1G channel expressed in HEK293 cells by whole-cell patch-clamp method | B | 5.87 | pIC50 | 1340 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of T-type Cav3.1 channel | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by manual patch-clamp assay | B | 6.07 | pIC50 | 860 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4219-4222 [PMID:20621730] |
| ChEMBL | Inhibition of alpha-1G T-type calcium channel expressed in HEK293 cells by electrophysiological method | B | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem (2007) 15: 1091-1105 [PMID:17074493] |
| ChEMBL | Concentration of the compounds required for inhibition of HEK293 cells (alpha1G T-type) | F | 6.08 | pIC50 | 840 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 3379-3384 [PMID:15177437] |
| ChEMBL | Inhibition of T-type CaV3.1 channel expressed in HEK293 cells assessed as inhibition of calcium current by automated patch-clamp assay | B | 6.08 | pIC50 | 830 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 4219-4222 [PMID:20621730] |
| ChEMBL | Inhibition of alpha-1G calcium channel in human HEK293 cells by whole-cell patch-clamp method | B | 6.08 | pIC50 | 830 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 1887-1890 [PMID:23395659] |
| ChEMBL | Inhibition of T-type CaV3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of calcium current by whole cell patch-clamp method | B | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 1565-1570 [PMID:24529871] |
| ChEMBL | Inhibition of t-type Cav3.1 channel (unknown origin) expressed in HEK293 cells assessed as inhibition of 50 ms depolarizing voltage step-induced current by whole cell patch-clamp method | B | 6.25 | pIC50 | 560 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 6656-6662 [PMID:24220170] |
| GtoPdb | - | - | 6.6 | pIC50 | 270 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Inhibition of human Cav3.1 alpha1G expressed in HEK293 cells assessed as inhibition of calcium influx by FLIPR assay | B | 6.7 | pIC50 | 200 | nM | IC50 | Bioorg Med Chem (2011) 19: 5628-5638 [PMID:21875808] |
| ChEMBL | Inhibition of Cav3.1 (unknown origin) | B | 7.19 | pIC50 | 64 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| Cav3.2/Voltage-gated T-type calcium channel alpha-1H subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1859] [GtoPdb: 536] [UniProtKB: O95180] | ||||||||
| ChEMBL | Inhibition of T-type Cav3.2 channel | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of human T-type calcium channel Cav3.2 expressed in T-Rex293 cells by whole cell patch clamp assay | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem Lett (2013) 23: 119-124 [PMID:23200256] |
| ChEMBL | Inhibition of recombinant Cav3.2 channel (unknown origin) expressed in HEK293 cells assessed as effect on calcium flux incubated for 3 mins by FLIPR assay | B | 6.74 | pIC50 | 181 | nM | IC50 | Bioorg Med Chem Lett (2015) 25: 3941-3946 [PMID:26231163] |
| ChEMBL | Antagonist activity at human alpha1H T-type calcium channel expressed in HEK293 cells by patch clamp technique | F | 6.89 | pIC50 | 130 | nM | IC50 | Bioorg Med Chem Lett (2008) 18: 474-478 [PMID:18160281] |
| ChEMBL | Inhibition of Cav3.2 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| GtoPdb | - | - | 7.2 | pIC50 | 69 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Antagonist activity against T-type calcium channel subunit alpha-1H assessed as inactivation of channel current by cell based patch clamp assay | F | 7.49 | pIC50 | 32 | nM | IC50 | Bioorg Med Chem Lett (2010) 20: 6375-6378 [PMID:20934333] |
| Cav3.3/Voltage-gated T-type calcium channel alpha-1I subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5558] [GtoPdb: 537] [UniProtKB: Q9P0X4] | ||||||||
| GtoPdb | - | - | 5.8 | pIC50 | 1500 | nM | IC50 | J Pharmacol Exp Ther (2000) 295: 302-8 [PMID:10991994] |
| ChEMBL | Inhibition of T-type Cav3.3 channel | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2010) 18: 5938-5944 [PMID:20659804] |
| ChEMBL | Inhibition of Cav3.3 (unknown origin) | B | 6.89 | pIC50 | 130 | nM | IC50 | J Med Chem (2017) 60: 9769-9789 [PMID:29116786] |
| ChEMBL | Inhibition of T-type calcium channel alpha1I by FLIPR | B | 6.9 | pIC50 | 126 | nM | IC50 | J Med Chem (2008) 51: 6471-6477 [PMID:18817368] |
| CatSper1 in Human [GtoPdb: 388] [UniProtKB: Q8NEC5] | ||||||||
| GtoPdb | Patch clamp electrophysiology, kinetic rapid mixing fluometry | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| CatSper2 in Human [GtoPdb: 389] [UniProtKB: Q96P56] | ||||||||
| GtoPdb | Patch clamp electrophysiology and kinetic rapid mixing fluometry. | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| CatSper3 in Human [GtoPdb: 390] [UniProtKB: Q86XQ3] | ||||||||
| GtoPdb | Patch clamp electrophysiology, kinetic rapid mixing fluometry. | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| CatSper4 in Human [GtoPdb: 391] [UniProtKB: Q7RTX7] | ||||||||
| GtoPdb | Patch clamp electrophysiology, kinetic rapid mixing fluometry. | - | 4.5 | pIC50 | 30000 | nM | IC50 | Nature (2011) 471: 382-6 [PMID:21412338] |
| Cav2.1 in Rat [GtoPdb: 532] [UniProtKB: P54282] | ||||||||
| GtoPdb | - | - | 6.5 | pIC50 | - | - | - | Neuropharmacology (2000) 39: 1-10 [PMID:10665814] |
| Cav2.3 in Rat [GtoPdb: 534] [UniProtKB: Q07652] | ||||||||
| GtoPdb | - | - | 6.4 | pIC50 | - | - | - | Neuropharmacology (2000) 39: 1-10 [PMID:10665814] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
