azimilide [Ligand Id: 2588] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL123558 (Azimilide)
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  • Potassium voltage-gated channel subfamily H member 2 in Guinea pig [ChEMBL: CHEMBL5557] [UniProtKB: O08703]
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  • Voltage-gated potassium channel subunit Kv7.1 in Guinea pig [ChEMBL: CHEMBL5135] [UniProtKB: O70344]
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  • Kv7.1 in Mouse [GtoPdb: 560] [UniProtKB: P97414]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL Inhibitory concentration against potassium channel HERG B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem Lett (2005) 15: 2886-2890 [PMID:15911273]
ChEMBL Inhibition of human Potassium channel HERG expressed in mammalian cells B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem Lett (2003) 13: 2773-2775 [PMID:12873512]
ChEMBL Inhibition of human ERG expressed in CHO cells by whole cell patch clamp technique B 5.85 pIC50 1412.54 nM IC50 Bioorg Med Chem (2008) 16: 6252-6260 [PMID:18448342]
ChEMBL Inhibition of human ERG B 6.25 pIC50 562.34 nM IC50 Eur J Med Chem (2011) 46: 618-630 [PMID:21185626]
ChEMBL Inhibition of human ERG in MCF7 cells B 6.25 pIC50 562.34 nM IC50 Eur J Med Chem (2009) 44: 1926-1932 [PMID:19110341]
ChEMBL K+ channel blocking activity in Chinese hamster ovary cells expressing HERG Kv11.1 F 6.25 pIC50 560 nM IC50 J Med Chem (2002) 45: 3844-3853 [PMID:12190308]
ChEMBL Inhibitory concentration against IKr potassium channel B 6.4 pIC50 400 nM IC50 Bioorg Med Chem Lett (2004) 14: 4771-4777 [PMID:15324906]
Potassium voltage-gated channel subfamily H member 2 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5557] [UniProtKB: O08703]
ChEMBL Inhibition of ERG in guinea pig ventricular myocytes assessed as blockade of rapid delayed rectifier potassium current by whole cell patch-clamp technique B 6.74 pIC50 180 nM IC50 Bioorg Med Chem Lett (2009) 19: 1477-1480 [PMID:19185489]
Voltage-gated potassium channel subunit Kv7.1 in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5135] [UniProtKB: O70344]
ChEMBL Inhibition of KVLQT1/minK in guinea pig ventricular myocytes assessed as blockade of slow delayed rectifier potassium current by whole cell patch-clamp technique B 6.62 pIC50 240 nM IC50 Bioorg Med Chem Lett (2009) 19: 1477-1480 [PMID:19185489]
Kv7.1 in Mouse [GtoPdb: 560] [UniProtKB: P97414]
GtoPdb - - 5.3 pIC50 - - - Br J Pharmacol (1997) 122: 187-9 [PMID:9313924]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]