Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
ChEMBL ligand: CHEMBL686 (CI-473, CN-35355, Contraflam, Dysman-250, Dysman-500, Gardan, INF-3355, J2.344B, M01AG01, Mefenamate, Mefenamic acid, Mefenaminic acid, Meflam 250, Meflam 500, Mendys, Mephenamic acid, Mephenaminic acid, NSC-94437, Opustan 250, Opustan 500, Ponstan, Ponstan fte, Ponstel) |
---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
---|---|---|---|---|---|---|---|---|
Acetylcholinesterase in Torpedo californica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4780] [UniProtKB: P04058] | ||||||||
ChEMBL | Inhibition of Torpedo californica eel AChE using acetylthiocholine/DTNB as substrate assessed as ROS-induced enzyme inactivation preincubated for 10 mins followed by substrate addition measured every 30 secs for 20 mins in presence of horseradish peroxidase and H2O2 | B | 5.21 | pIC50 | 6120 | nM | IC50 | Medchemcomm (2011) 2: 406-412 |
Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
ChEMBL | Inhibition of wild-type N-terminal 6-His tagged AKR1B10 (unknown origin) expressed in Escherichia coli BL21(DE3) assessed as pyridine-3-aldehyde reduction by spectrophotometry | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2015) 58: 2047-2067 [PMID:25375908] |
Aldo-keto reductase family 1 member C1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5905] [UniProtKB: Q04828] | ||||||||
ChEMBL | Inhibition of human recombinant AKR1C1 assessed as 1-acenaphthenol oxidation by spectrophotometry | B | 6.09 | pKi | 810 | nM | Ki | J Med Chem (2012) 55: 7417-7424 [PMID:22881866] |
ChEMBL | Inhibition of AKR1C1 (unknown origin) | B | 5.41 | pIC50 | 3910 | nM | IC50 | Eur J Med Chem (2013) 62: 738-744 [PMID:23454516] |
Aldo-keto reductase family 1 member C2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5847] [UniProtKB: P52895] | ||||||||
ChEMBL | Inhibition of human recombinant AKR1C2 assessed as 1-acenaphthenol oxidation by spectrophotometry | B | 6.66 | pKi | 220 | nM | Ki | J Med Chem (2012) 55: 7417-7424 [PMID:22881866] |
ChEMBL | Inhibition of AKR1C2 (unknown origin) | B | 5.16 | pIC50 | 6970 | nM | IC50 | Eur J Med Chem (2013) 62: 738-744 [PMID:23454516] |
AKR1C3/Aldo-keto-reductase family 1 member C3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4681] [GtoPdb: 1382] [UniProtKB: P42330] | ||||||||
ChEMBL | Inhibition of human recombinant AKR1C3 assessed as 1-acenaphthenol oxidation by spectrophotometry | B | 6.52 | pKi | 300 | nM | Ki | J Med Chem (2012) 55: 7417-7424 [PMID:22881866] |
ChEMBL | Inhibition of AKR1C3 (unknown origin) | B | 6.25 | pIC50 | 560 | nM | IC50 | Eur J Med Chem (2013) 62: 738-744 [PMID:23454516] |
Aldo-keto reductase family 1 member C4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4999] [UniProtKB: P17516] | ||||||||
ChEMBL | Inhibition of AKR1C4 (unknown origin) | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2013) 62: 738-744 [PMID:23454516] |
aldo-keto reductase family 1 member B/Aldose reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1900] [GtoPdb: 2768] [UniProtKB: P15121] | ||||||||
ChEMBL | Inhibition of human AR by fluorescence assay | B | 4.11 | pIC50 | 77000 | nM | IC50 | J Med Chem (2015) 58: 2047-2067 [PMID:25375908] |
COX-1 /Cyclooxygenase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL221] [GtoPdb: 1375] [UniProtKB: P23219] | ||||||||
GtoPdb | - | - | 4.6 | pIC50 | 25000 | nM | IC50 | Eur J Med Chem (2013) 62: 738-44 [PMID:23454516] |
ChEMBL | Inhibition of COX1 (unknown origin) | B | 4.6 | pIC50 | 25000 | nM | IC50 | Eur J Med Chem (2013) 62: 738-744 [PMID:23454516] |
ChEMBL | DRUGMATRIX: Cyclooxygenase COX-1 enzyme inhibition (substrate: Arachidonic acid) | B | 6.94 | pIC50 | 116 | nM | IC50 | DrugMatrix in vitro pharmacology data |
COX-2 /Cyclooxygenase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL230] [GtoPdb: 1376] [UniProtKB: P35354] | ||||||||
ChEMBL | Inhibition of COX2 (unknown origin) | B | 5.54 | pIC50 | 2900 | nM | IC50 | Eur J Med Chem (2013) 62: 738-744 [PMID:23454516] |
GtoPdb | - | - | 5.54 | pIC50 | 2900 | nM | IC50 | Eur J Med Chem (2013) 62: 738-44 [PMID:23454516] |
ChEMBL | DRUGMATRIX: Cyclooxygenase COX-2 enzyme inhibition (substrate: Arachidonic acid) | B | 6.22 | pIC50 | 602 | nM | IC50 | DrugMatrix in vitro pharmacology data |
dihydrofolate reductase/Dihydrofolate reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL202] [GtoPdb: 2603] [UniProtKB: P00374] | ||||||||
ChEMBL | Inhibition of human DHFR in presence of DHF and NADPH by UV-vis spectrometry by Lineweaver-Burk plot analysis | B | 4.14 | pKi | 72000 | nM | Ki | J Med Chem (2020) 63: 8314-8324 [PMID:32658475] |
myeloperoxidase/Myeloperoxidase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2439] [GtoPdb: 2789] [UniProtKB: P05164] | ||||||||
ChEMBL | Inhibition of recombinant MPO (unknown origin) assessed as reduction in LDL oxidation in presence of H2O2 and HCl after 5 mins by ELISA | B | 5.66 | pIC50 | 2210 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
ChEMBL | Inhibition of recombinant MPO (unknown origin) assessed as reduction in taurine chloramine production preincubated with enzyme and taurine followed by H2O2 addition measured after 5 mins | B | 6.01 | pIC50 | 980 | nM | IC50 | J Med Chem (2017) 60: 6563-6586 [PMID:28671460] |
NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8] | ||||||||
ChEMBL | Inhibition of NLRP3 inflammasome activation in LPS-primed C57BL/6 mouse bone marrow derived macrophages preincubated for 15 mins followed by addition of ATP and measured after 1 hr by ELISA | B | 4.6 | pIC50 | 25000 | nM | IC50 | Eur J Med Chem (2020) 185: 111822-111822 [PMID:31699536] |
Nicotinate phosphoribosyltransferase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523354] [UniProtKB: Q6XQN6] | ||||||||
ChEMBL | Inhibition of NAPRT (unknown origin) | B | 10.3 | pKi | 0.05 | nM | Ki | WO-2017162840-A1. Sensitization of cancer cells to nampt inhibitors by nicotinic acid phosphoribosyltransferase neutralization (null) |
TRPA1/Transient receptor potential cation channel subfamily A member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6007] [GtoPdb: 485] [UniProtKB: O75762] | ||||||||
ChEMBL | Agonist activity at human TRPA1 in WI38 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.21 | pEC50 | 61000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.78 | pEC50 | 16595.87 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL | Agonist activity at human TRPA1 expressed in HEK293 cells assessed as increase in calcium influx by Fluo-4-AM dye based fluorescence assay | B | 4.8 | pEC50 | 16000 | nM | EC50 | Eur J Med Chem (2019) 170: 141-156 [PMID:30878828] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]