tamibarotene [Ligand Id: 2648] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL25202 (Am80, AM-80, Amnoid, INNO-507, NSC-608000, OP-01, RR-110, Sy-1425, SY-1425, Tamibarotene, TM-411, TOS-80T) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Flavin reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5019] [UniProtKB: P30043] | ||||||||
| ChEMBL | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | B | 5.86 | pKd | 1380.38 | nM | Kd | J Med Chem (2022) 65: 2548-2557 [PMID:34957824] |
| ChEMBL | Binding affinity to human N-terminal His6-tagged and thrombin cleavage fused BLVRB expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant by isothermal titration calorimetry | B | 5.86 | pKd | 1380 | nM | Kd | J Med Chem (2022) 65: 2548-2557 [PMID:34957824] |
| Retinoic acid receptor-α/Retinoic acid receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2055] [GtoPdb: 590] [UniProtKB: P10276] | ||||||||
| ChEMBL | Agonistic activity towards retinoic acid receptor-alpha | F | 8.19 | pKi | 6.5 | nM | Ki | J Med Chem (1997) 40: 4222-4234 [PMID:9435893] |
| GtoPdb | - | - | 6.9 | pIC50 | - | - | - |
J Med Chem (1988) 31: 2182-92 [PMID:3184125]; Mol Cell Biol (1995) 15: 3540-51 [PMID:7791761]; Curr Pharm Des (2000) 6: 25-58 [PMID:10637371] |
| ChEMBL | Binding affinity for Retinoic Acid Receptor alpha (RAR alpha) | B | 7.11 | pIC50 | 78 | nM | IC50 | J Med Chem (2000) 43: 409-419 [PMID:10669568] |
| ChEMBL | Agonist activity at RARalpha | F | 7.35 | pEC50 | 45 | nM | EC50 | J Med Chem (2010) 53: 6779-6810 [PMID:20925433] |
| GtoPdb | - | - | 7.35 | pEC50 | 45 | nM | EC50 | J Med Chem (2010) 53: 6779-810 [PMID:20925433] |
| Retinoic acid receptor-β/Retinoic acid receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2008] [GtoPdb: 591] [UniProtKB: P10826] | ||||||||
| ChEMBL | Agonistic activity towards retinoic acid receptor-beta | F | 7.52 | pKi | 30 | nM | Ki | J Med Chem (1997) 40: 4222-4234 [PMID:9435893] |
| ChEMBL | Agonist activity at RARbeta | F | 6.63 | pEC50 | 235 | nM | EC50 | J Med Chem (2010) 53: 6779-6810 [PMID:20925433] |
| GtoPdb | - | - | 6.63 | pEC50 | 235 | nM | EC50 | J Med Chem (2010) 53: 6779-810 [PMID:20925433] |
| Retinoic acid receptor-γ/Retinoic acid receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2003] [GtoPdb: 592] [UniProtKB: P13631] | ||||||||
| ChEMBL | Agonist activity at RARgamma | F | 6.23 | pEC50 | 591 | nM | EC50 | J Med Chem (2010) 53: 6779-6810 [PMID:20925433] |
| GtoPdb | - | - | 6.23 | pEC50 | 591 | nM | EC50 | J Med Chem (2010) 53: 6779-810 [PMID:20925433] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
