daidzein [Ligand Id: 2828] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL8145 (4',7-dihydroxyisoflavone, Daidzein) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| aldehyde dehydrogenase 2 family member/Aldehyde dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1935] [GtoPdb: 2595] [UniProtKB: P05091] | ||||||||
| ChEMBL | Inhibition of Hamster Liver mitochondrial ALDH-2 | B | 5.05 | pIC50 | 9000 | nM | IC50 | J Med Chem (2000) 43: 4169-4179 [PMID:11063613] |
| ChEMBL | Inhibition of hamster liver aldehyde dehydrogenase ALDH-2 | B | 5.05 | pIC50 | 9000 | nM | IC50 | J Med Chem (2001) 44: 3320-3328 [PMID:11563931] |
| Aldo-keto reductase family 1 member B10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5983] [UniProtKB: O60218] | ||||||||
| ChEMBL | Inhibition of recombinant human N-terminal His6-tagged AKR1B10 expressed in Escherichia coli BL21 cells using all-trans-retinal as substrate incubated for 15 mins by HPLC method | B | 4.49 | pIC50 | 32200 | nM | IC50 | J Nat Prod (2015) 78: 2666-2674 [PMID:26529431] |
| Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265] | ||||||||
| ChEMBL | Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry | B | 1.15 | pIC50 | 1.15 | - | logIC50 | Med Chem Res (2012) 21: 3984-3993 |
| carbonic anhydrase 1/Carbonic anhydrase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL261] [GtoPdb: 2597] [UniProtKB: P00915] | ||||||||
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393] |
| carbonic anhydrase 2/Carbonic anhydrase II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL205] [GtoPdb: 3092] [UniProtKB: P00918] | ||||||||
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay | B | 5 | pKi | >10000 | nM | Ki | Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393] |
| carbonic anhydrase 4/Carbonic anhydrase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3729] [GtoPdb: 2599] [UniProtKB: P22748] | ||||||||
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 4 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay | B | 6.14 | pKi | 718.7 | nM | Ki | Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393] |
| carbonic anhydrase 7/Carbonic anhydrase VII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2326] [GtoPdb: 2749] [UniProtKB: P43166] | ||||||||
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 7 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay | B | 8.38 | pKi | 4.2 | nM | Ki | Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393] |
| carbonic anhydrase 12/Carbonic anhydrase XII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3242] [GtoPdb: 2747] [UniProtKB: O43570] | ||||||||
| ChEMBL | Inhibition of human recombinant carbonic anhydrase 12 preincubated for 15 mins at room temperature/6 hrs at 4 deg C by stopped-flow CO2 hydration assay | B | 7.25 | pKi | 56.4 | nM | Ki | Bioorg Med Chem (2015) 23: 7219-7225 [PMID:26498393] |
| CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] | ||||||||
| ChEMBL | Inhibition of human aromatase expressed in CHO cells | B | 4 | pKi | 100000 | nM | Ki | Bioorg Med Chem (2008) 16: 8466-8470 [PMID:18778944] |
| Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] | ||||||||
| ChEMBL | Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha | B | 5.74 | pKi | 1800 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1839-1842 [PMID:11459643] |
| ChEMBL | Displacement of [3H]estradiol from human recombinant ERalpha | B | 4.77 | pIC50 | 17000 | nM | IC50 | J Nat Prod (2002) 65: 1749-1753 [PMID:12502307] |
| ChEMBL | Inhibition of binding of 17 beta-estradiol to human Estrogen receptor alpha | B | 5.2 | pIC50 | 6300 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1839-1842 [PMID:11459643] |
| ChEMBL | Binding affinity against human estrogen receptor alpha in competitive binding assay | B | 5.67 | pIC50 | 2160 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1417-1421 [PMID:15006374] |
| ChEMBL | Displacement of fluorescent labeled ES2 from recombinant ERalpha | B | 6.35 | pIC50 | 450 | nM | IC50 | J Med Chem (2010) 53: 6153-6163 [PMID:20669983] |
| Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] | ||||||||
| ChEMBL | Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta | B | 6.52 | pKi | 300 | nM | Ki | Bioorg Med Chem Lett (2001) 11: 1839-1842 [PMID:11459643] |
| ChEMBL | Binding affinity for human Estrogen receptor beta | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2005) 48: 3463-3466 [PMID:15887952] |
| ChEMBL | Binding affinity for human Estrogen receptor beta | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2005) 48: 3463-3466 [PMID:15887952] |
| ChEMBL | Binding Assay: The binding affinity and selectivity of candidate molecules yielded from database screening were determined by a fluorescent polarization competitive binding assay using purified baculovirus-expressed human ER beta or ER alpha and a fluorescent estrogen ligand EL Red (PanVera Corp.). | B | 5.55 | pIC50 | 2800 | nM | IC50 | US-8552057-B2. Phytoestrogenic formulations for alleviation or prevention of neurodegenerative diseases (2013) |
| ChEMBL | Displacement of [3H]estradiol from human recombinant ERbeta | B | 5.92 | pIC50 | 1200 | nM | IC50 | J Nat Prod (2002) 65: 1749-1753 [PMID:12502307] |
| ChEMBL | Inhibition of binding of 17 beta-estradiol to human Estrogen receptor beta | B | 5.96 | pIC50 | 1100 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1839-1842 [PMID:11459643] |
| ChEMBL | Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay | B | 6.52 | pIC50 | 303 | nM | IC50 | Bioorg Med Chem Lett (2004) 14: 1417-1421 [PMID:15006374] |
| Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7] | ||||||||
| ChEMBL | Inhibition of FabZ | B | 4.52 | pIC50 | 30000 | nM | IC50 | J Med Chem (2006) 49: 3345-3353 [PMID:16722653] |
| Neuraminidase in Influenza A virus (A/Puerto Rico/8/1934(H1N1)) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2051] [UniProtKB: P03468] | ||||||||
| ChEMBL | Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | B | 0.97 | pIC50 | 0.97 | - | logIC50 | Eur J Med Chem (2010) 45: 1724-1730 [PMID:20116898] |
| Neuraminidase in Influenza A virus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6135] [UniProtKB: B4URF0] | ||||||||
| ChEMBL | Inhibition of Influenza A Jiangsu/10/2003 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | B | 4.33 | pIC50 | 46800 | nM | IC50 | Bioorg Med Chem (2008) 16: 7141-7147 [PMID:18640042] |
| ChEMBL | Inhibition of Influenza A PR/8/34 H1N1 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | B | 4.43 | pIC50 | 37100 | nM | IC50 | Bioorg Med Chem (2008) 16: 7141-7147 [PMID:18640042] |
| ChEMBL | Inhibition of Influenza A Jinan/15/90 H3N2 virus neuraminidase activity by MUN-ANA substrate based fluorimetric assay | B | 4.58 | pIC50 | 26600 | nM | IC50 | Bioorg Med Chem (2008) 16: 7141-7147 [PMID:18640042] |
| proteasome 20S subunit beta 5/Proteasome Macropain subunit MB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4662] [GtoPdb: 2406] [UniProtKB: P28074] | ||||||||
| ChEMBL | Inhibition of chymotrypsin-like activity of purified human erythrocyte 20S proteasome assessed as decrease in AMC hydrolysis using Suc-LLVY-AMC as substrate preincubated for 10 mins and measured by fluorescence based method | B | 4 | pIC50 | >100000 | nM | IC50 | Eur J Med Chem (2019) 167: 291-311 [PMID:30776692] |
| transthyretin/Transthyretin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3194] [GtoPdb: 2851] [UniProtKB: P02766] | ||||||||
| ChEMBL | Inhibition of transthyretin V30M mutant (unknown origin) expressed in Escherichia coli assessed as inhibition of sodium acetate-mediated aggregation preincubated for 30 mins followed by sodium acetate addition measured after 96 hrs by thioflavin T assay | B | 4.8 | pIC50 | 16000 | nM | IC50 | J Med Chem (2014) 57: 1090-1096 [PMID:24422526] |
| Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3762] [GtoPdb: 529] [UniProtKB: P22002] | ||||||||
| ChEMBL | Inhibition of L-type calcium channel measured using whole-cell patch clamp in rat ventricular myocytes | F | 4.92 | pIC50 | 12000 | nM | IC50 | J Appl Toxicol (2012) 32: 858-866 [PMID:22761000] |
| ChEMBL | Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in rat ventricular myocytes | F | 4.92 | pIC50 | 12000 | nM | IC50 | IC50 data for the L-type calcium channel extracted from a set of literature articles |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
