ChEMBL ligand: CHEMBL386630 (Androderm, Androgel, Androgel 1%, Andropatch, Axiron, Delatestryl, Fortesta, Intrinsa, Natesto, NSC-9700, Striant, Striant sr, Testim, TESTIM, Testim 1%, Testoderm, Testoderm tts, Testogel, Testopatch, Testopel, Testoral, Testosterone, Testosterone ciii, Tostran, Vogelxo)
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human [ChEMBL: CHEMBL4931] [UniProtKB: Q15125] There should be some charts here, you may need to enable JavaScript!
Alpha-synuclein in Human [ChEMBL: CHEMBL6152] [UniProtKB: P37840] There should be some charts here, you may need to enable JavaScript!
Androgen receptor/Androgen Receptor in Human [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275] Androgen receptor/Androgen Receptor in Mouse [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091] Androgen receptor/Androgen Receptor in Rat [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207] There should be some charts here, you may need to enable JavaScript!
C-8 sterol isomerase in Saccharomyces cerevisiae S288c [ChEMBL: CHEMBL3224] [UniProtKB: P32352] There should be some charts here, you may need to enable JavaScript!
Constitutive androstane receptor in Mouse [ChEMBL: CHEMBL3069] [UniProtKB: O35627] There should be some charts here, you may need to enable JavaScript!
Corticosteroid binding globulin in Human [ChEMBL: CHEMBL2421] [UniProtKB: P08185] There should be some charts here, you may need to enable JavaScript!
CYP19A1/Cytochrome P450 19A1 in Human [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511] There should be some charts here, you may need to enable JavaScript!
CYP51A1/Cytochrome P450 51 in Human [ChEMBL: CHEMBL3849] [GtoPdb: 1374] [UniProtKB: Q16850] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-α/Estrogen receptor alpha in Human [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372] There should be some charts here, you may need to enable JavaScript!
Estrogen receptor-β/Estrogen receptor beta in Human [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731] There should be some charts here, you may need to enable JavaScript!
Glucocorticoid receptor in Human [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150] There should be some charts here, you may need to enable JavaScript!
GPBA receptor/G-protein coupled bile acid receptor 1 in Human [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6] There should be some charts here, you may need to enable JavaScript!
Progesterone receptor in Bovine [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0] There should be some charts here, you may need to enable JavaScript!
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720] There should be some charts here, you may need to enable JavaScript!
Solute carrier organic anion transporter family member 1A1 in Rat [ChEMBL: CHEMBL1781859] [UniProtKB: P46720] There should be some charts here, you may need to enable JavaScript!
Testis-specific androgen-binding protein in Human [ChEMBL: CHEMBL3305] [UniProtKB: P04278] There should be some charts here, you may need to enable JavaScript!
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-beta-hydroxysteroid-delta(8),delta(7)-isomerase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4931] [UniProtKB: Q15125]
ChEMBL	Affinity for human EMP expressed in ERG2 deficient strain of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine as radioligand	B	4	pKi	>100000	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Alpha-synuclein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6152] [UniProtKB: P37840]
ChEMBL	Inhibition of alpha-synuclein aggregation (unknown origin) incubated for 8 days by thioflavin S based fluorescence assay	B	4.01	pIC50	96800	nM	IC50	Eur J Med Chem (2019) 167: 10-36 [PMID:30743095]
Androgen receptor/Androgen Receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1871] [GtoPdb: 628] [UniProtKB: P10275]
ChEMBL	Displacement of fluorescent-tagged R1881 from androgen receptor after 4 hrs by fluorometric assay	B	7.54	pKi	29	nM	Ki	ACS Med Chem Lett (2011) 2: 124-129 [PMID:24900290]
ChEMBL	Binding affinity to androgen receptor by fluorescence binding assay	B	7.52	pIC50	30	nM	IC50	Bioorg Med Chem Lett (2010) 20: 7516-7520 [PMID:21036041]
ChEMBL	Displacement of [3H]R1881 from wild type human androgen receptor expressed in COS-1 cells co-transfected with pSG5 after 15 mins by scintillation assay	B	8.34	pIC50	4.57	nM	IC50	J Med Chem (2012) 55: 6316-6327 [PMID:22746350]
ChEMBL	Displacement of [3H]R1881 from pSG5-tagged human androgen receptor expressed in COS1 cells assessed as relative binding inhibition	B	8.37	pIC50	4.27	nM	IC50	J Med Chem (2015) 58: 1569-1574 [PMID:25646649]
ChEMBL	Antagonist activity against pSG5-tagged human androgen receptor expressed in COS1 cells assessed as reduction in receptor-mediated transcriptional activity by AR-regulated rat probasin promoter fragment driven firefly luciferase reporter assay	B	8.38	pIC50	4.17	nM	IC50	J Med Chem (2015) 58: 1569-1574 [PMID:25646649]
ChEMBL	Inhibition of human androgen receptor expressed in Escherichia coli	B	8.41	pIC50	3.9	nM	IC50	J Med Chem (2004) 47: 4985-4988 [PMID:15456242]
ChEMBL	Binding affinity at AR	B	8.57	pIC50	2.7	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6295-6298 [PMID:17890084]
ChEMBL	Binding affinity to androgen receptor	B	8.57	pIC50	2.7	nM	IC50	Bioorg Med Chem Lett (2007) 17: 2944-2948 [PMID:17448656]
ChEMBL	Inhibitory activity against AR	B	8.57	pIC50	2.7	nM	IC50	Bioorg Med Chem Lett (2006) 16: 834-838 [PMID:16309907]
ChEMBL	Agonist activity at androgen receptor in human MDA-KB2 cells transfected with MMTV linked luciferase assessed as transcriptional activation by luciferase reporter gene assay	F	8.5	pEC50	3.16	nM	EC50	J Med Chem (2009) 52: 7186-7191 [PMID:19856921]
Androgen receptor/Androgen Receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3056] [GtoPdb: 628] [UniProtKB: P19091]
ChEMBL	Agonist activity at androgen receptor in mouse NIH3T3 cells transiently transfected with beta-galactosidase reporter gene assessed as cellular transformation by R-SAT assay	F	8.7	pEC50	2	nM	EC50	J Med Chem (2009) 52: 7186-7191 [PMID:19856921]
Androgen receptor/Androgen Receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3072] [GtoPdb: 628] [UniProtKB: P15207]
ChEMBL	Binding affinity against rat prostate cytosolic Androgen receptor using [3H]mibolerone as radioligand	B	8.31	pKi	4.9	nM	Ki	Bioorg Med Chem Lett (2001) 11: 1045-1047 [PMID:11327585]
ChEMBL	Inhibition of rat prostate cytosolic androgen receptor	B	8.31	pKi	4.9	nM	Ki	Bioorg Med Chem Lett (2004) 14: 5285-5288 [PMID:15454212]
ChEMBL	Displacement of [3H]Mibolerone from rat recombinant androgen receptor expressed in Escherichia coli after 4 hrs	B	8.37	pKi	4.3	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	8.39	pKi	4.11	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of [3H]mibolerone binding to cytosolic androgen receptor of rat ventral prostate	B	8.85	pKi	1.41	nM	Ki	J Med Chem (2005) 48: 917-925 [PMID:15715462]
ChEMBL	Inhibitory constant against rat prostate cytosol androgen receptor using [3H]mibolerone	B	8.85	pKi	1.4	nM	Ki	J Med Chem (2000) 43: 3344-3347 [PMID:10966753]
ChEMBL	Inhibitory concentration against recombinant rat androgen receptor expressed in Escherichia coli using [3H]methyltrienolone (R 1881)	B	5.51	pIC50	3090.3	nM	IC50	J Med Chem (2005) 48: 5666-5674 [PMID:16134935]
GtoPdb	-	-	7.8	pIC50	-	-	-	Chem Res Toxicol (2003) 16: 1338-58 [PMID:14565775]
ChEMBL	Displacement of [3H]Mibolerone from rat recombinant androgen receptor expressed in Escherichia coli after 4 hrs	B	8.19	pIC50	6.5	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	DRUGMATRIX: Androgen (Testosterone) AR radioligand binding (ligand: [3H] Mibolerone)	B	8.21	pIC50	6.17	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	In vitro antagonist activity against rat prostatic androgen receptor (AR)	F	8.49	pIC50	3.2	nM	IC50	J Med Chem (1986) 29: 2298-2315 [PMID:3783591]
C-8 sterol isomerase in Saccharomyces cerevisiae S288c (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3224] [UniProtKB: P32352]
ChEMBL	Affinity for ERG2 of Saccharomyces cerevisiae using [3H]ifenprodil or (+)-[3H]pentazocine radioligand	B	5.11	pKi	7760	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Constitutive androstane receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3069] [UniProtKB: O35627]
ChEMBL	Inhibitory concentration against mammalian m-constitutive androstane receptor (mCAR) activity	B	4.52	pIC50	30000	nM	IC50	J Med Chem (2003) 46: 4687-4695 [PMID:14561088]
Corticosteroid binding globulin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2421] [UniProtKB: P08185]
ChEMBL	In silico binding affinity to human corticosteriod binding globulin	B	5.72	pKd	5.72	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Binding affinity to human CBG receptor (corticosteroid-binding globulins)	B	6.72	pKi	190.55	nM	Ki	J Med Chem (2004) 47: 2732-2742 [PMID:15139751]
CYP19A1/Cytochrome P450 19A1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1978] [GtoPdb: 1362] [UniProtKB: P11511]
ChEMBL	Inhibition of human placental aromatase Cytochrome P450 19A1	B	6.22	pKi	600	nM	Ki	J Med Chem (1983) 26: 50-54 [PMID:6827528]
CYP51A1/Cytochrome P450 51 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3849] [GtoPdb: 1374] [UniProtKB: Q16850]
ChEMBL	Inhibition of human CYP51 expressed in Topp 3 cells by lanosterol demethylase assay	B	4.3	pIC50	50000	nM	IC50	Drug Metab Dispos (2007) 35: 493-500 [PMID:17194716]
Estrogen receptor-α/Estrogen receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL206] [GtoPdb: 620] [UniProtKB: P03372]
ChEMBL	Binding affinity to human ERalpha	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 834-838 [PMID:16309907]
ChEMBL	Binding affinity to human recombinant ERalpha by scintillation proximity assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 2944-2948 [PMID:17448656]
Estrogen receptor-β/Estrogen receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL242] [GtoPdb: 621] [UniProtKB: Q92731]
ChEMBL	Binding affinity to human ERbeta	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2006) 16: 834-838 [PMID:16309907]
ChEMBL	Binding affinity to human recombinant ERbeta by scintillation proximity assay	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 2944-2948 [PMID:17448656]
ChEMBL	Binding affinity at human recombinant ERbeta	B	5	pIC50	>10000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 6295-6298 [PMID:17890084]
Glucocorticoid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2034] [GtoPdb: 625] [UniProtKB: P04150]
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	5.84	pKi	1457	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Glucocorticoid radioligand binding (ligand: [3H] Dexamethasone)	B	5.49	pIC50	3206	nM	IC50	DrugMatrix in vitro pharmacology data
GPBA receptor/G-protein coupled bile acid receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5409] [GtoPdb: 37] [UniProtKB: Q8TDU6]
ChEMBL	Agonist activity at human TGR5 expressed in CHO cells by luciferase assay	F	4.74	pEC50	18300	nM	EC50	J Med Chem (2008) 51: 1831-1841 [PMID:18307294]
Progesterone receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1909044] [UniProtKB: Q690N0]
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	6.6	pKi	252	nM	Ki	DrugMatrix in vitro pharmacology data
ChEMBL	DRUGMATRIX: Progesterone radioligand binding (ligand: [3H] R-5020)	B	5.71	pIC50	1935	nM	IC50	DrugMatrix in vitro pharmacology data
sigma non-opioid intracellular receptor 1/Sigma opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL287] [GtoPdb: 2552] [UniProtKB: Q99720]
ChEMBL	Affinity for sigma receptor type 1 of guinea pig using [3H]ifenprodil or (+)-[3H]pentazocine radioligand	B	5.92	pKi	1200	nM	Ki	J Med Chem (2005) 48: 4754-4764 [PMID:16033255]
Solute carrier organic anion transporter family member 1A1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1781859] [UniProtKB: P46720]
ChEMBL	TP_TRANSPORTER: inhibition of E217betaG uptake in Oatp1-expressing HeLa cells	F	5.27	pKi	5400	nM	Ki	Am J Physiol (1996) 270: F326-F331 [PMID:8779894]
Testis-specific androgen-binding protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3305] [UniProtKB: P04278]
ChEMBL	Binding affinity towards human testosterone binding globulin.	B	8.2	pKd	8.2	-	-Log Kdiss	J Med Chem (1997) 40: 3161-3172 [PMID:9379435]
ChEMBL	Displacement of [3H]5alpha dihydrotestosterone from human sex hormone binding globulin	B	9.2	pKd	0.63	nM	Kd	J Med Chem (2008) 51: 2047-2056 [PMID:18330978]
ChEMBL	Displacement of [3H]DHT from human SHBG	B	7.85	pIC50	14	nM	IC50	J Med Chem (2006) 49: 7466-7478 [PMID:17149875]
Cav1.2/Voltage-gated L-type calcium channel alpha-1C subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1940] [GtoPdb: 529] [UniProtKB: Q13936]
ChEMBL	Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit	F	7.42	pIC50	38.4	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]
ChEMBL	Inhibition of L-type calcium channel measured using 2-electrode voltage-clamp in human embryonic kidney cells heterologically expressing alpha-1C subunit	F	7.47	pIC50	34	nM	IC50	J Appl Toxicol (2012) 32: 858-866 [PMID:22761000]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]