dioctanoylglycerol pyrophosphate [Ligand Id: 2916] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL191055 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| LPA1 receptor/Lysophosphatidic acid receptor Edg-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3819] [GtoPdb: 272] [UniProtKB: Q92633] | ||||||||
| GtoPdb | - | - | 5.18 | pKi | 6600 | nM | Ki |
Curr Med Chem (2008) 15: 2122-31 [PMID:18781939]; Mol Pharmacol (2001) 60: 776-84 [PMID:11562440] |
| ChEMBL | Binding affinity for Lysophosphatidic acid receptor 1 expressed in RH7777 rat hepatoma cells | B | 5.37 | pKi | 4300 | nM | Ki | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| ChEMBL | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA1 receptor | F | 5.26 | pIC50 | 5500 | nM | IC50 | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| LPA3 receptor/Lysophosphatidic acid receptor Edg-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3250] [GtoPdb: 274] [UniProtKB: Q9UBY5] | ||||||||
| ChEMBL | Binding affinity for Lysophosphatidic acid receptor 3 expressed in RH7777 rat hepatoma cells | B | 6.69 | pKi | 202 | nM | Ki | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| GtoPdb | - | - | 7 | pKi | 3330 | nM | Ki |
Mol Pharmacol (2003) 64: 994-1005 [PMID:14500756]; Mol Pharmacol (2001) 60: 776-84 [PMID:11562440] |
| ChEMBL | Inhibition of LPA-induced calcium transients in RH7777 rat hepatoma cells expressing LPA3 receptor | F | 6.34 | pIC50 | 454 | nM | IC50 | J Med Chem (2005) 48: 4919-4930 [PMID:16033271] |
| GtoPdb | - | - | 6.97 | pIC50 | 106 | nM | IC50 | Mol Pharmacol (2001) 60: 776-84 [PMID:11562440] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
