arecaidine propargyl ester [Ligand Id: 295] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL128365 (Arecaidine Propargyl Ester) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor DM1 in Drosophila melanogaster (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2366467] [UniProtKB: P16395] | ||||||||
| ChEMBL | Displacement of [3H]AF-DX 384 from Drosophila melanogaster mAChR by scintillation counting | B | 5.28 | pKi | 5200 | nM | Ki | J Agric Food Chem (2007) 55: 2276-2281 [PMID:17319687] |
| ChEMBL | Displacement of [3H]QNB from Drosophila melanogaster mAChR by scintillation counting | B | 5.35 | pKi | 4490 | nM | Ki | J Agric Food Chem (2007) 55: 2276-2281 [PMID:17319687] |
| M1 receptor/Muscarinic acetylcholine receptor M1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL216] [GtoPdb: 13] [UniProtKB: P11229] | ||||||||
| ChEMBL | Binding affinity to cloned human muscarinic M1 receptor expressed in CHO cells | B | 5.91 | pKi | 1230.27 | nM | Ki | J Med Chem (2006) 49: 1925-1931 [PMID:16539379] |
| GtoPdb | - | - | 6.4 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| M2 receptor/Muscarinic acetylcholine receptor M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL211] [GtoPdb: 14] [UniProtKB: P08172] | ||||||||
| GtoPdb | - | - | 5.7 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Binding affinity to cloned human muscarinic M2 receptor expressed in CHO cells | B | 7.06 | pKi | 87.1 | nM | Ki | J Med Chem (2006) 49: 1925-1931 [PMID:16539379] |
| M3 receptor/Muscarinic acetylcholine receptor M3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL245] [GtoPdb: 15] [UniProtKB: P20309] | ||||||||
| GtoPdb | - | - | 5.7 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Binding affinity to cloned human muscarinic M3 receptor expressed in CHO cells | B | 6.07 | pKi | 851.14 | nM | Ki | J Med Chem (2006) 49: 1925-1931 [PMID:16539379] |
| M4 receptor/Muscarinic acetylcholine receptor M4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1821] [GtoPdb: 16] [UniProtKB: P08173] | ||||||||
| GtoPdb | - | - | 5.9 | pKi | - | - | - | Mol Pharmacol (1997) 52: 172-9 [PMID:9224827] |
| ChEMBL | Binding affinity to cloned human muscarinic M4 receptor expressed in CHO cells | B | 6.01 | pKi | 977.24 | nM | Ki | J Med Chem (2006) 49: 1925-1931 [PMID:16539379] |
| M5 receptor/Muscarinic acetylcholine receptor M5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2035] [GtoPdb: 17] [UniProtKB: P08912] | ||||||||
| ChEMBL | Binding affinity to cloned human muscarinic M5 receptor expressed in CHO cells | B | 6.03 | pKi | 933.25 | nM | Ki | J Med Chem (2006) 49: 1925-1931 [PMID:16539379] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
