compound 18 [PMID: 8426367] [Ligand Id: 2961] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL133434 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CYP51A1/Cytochrome P450 51 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4981] [GtoPdb: 1374] [UniProtKB: Q64654] | ||||||||
| ChEMBL | Inhibition rat liver microsome cytochrome P450DM | B | 5.04 | pIC50 | 9100 | nM | IC50 | J Med Chem (1993) 36: 410-416 [PMID:8426367] |
| ChEMBL | Inhibition rat liver microsome cytochrome P450DM | B | 5.57 | pIC50 | 2700 | nM | IC50 | J Med Chem (1993) 36: 410-416 [PMID:8426367] |
| hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] | ||||||||
| ChEMBL | Inhibition of HMG-coA Reductase enzyme in AR45 cells | B | 4.7 | pIC50 | >20000 | nM | IC50 | J Med Chem (1993) 36: 410-416 [PMID:8426367] |
| GtoPdb | Inhibition of HMG-CoA reductase | - | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1993) 36: 410-6 [PMID:8426367] |
| ChEMBL | Inhibition of HMG-coA Reductase enzyme in chinese hamster ovary cells | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (1993) 36: 410-416 [PMID:8426367] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
