compound 1 [Overhand et al., 1997] [Ligand Id: 3065] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL86513 ((2E,6E)-Farnesylbisphosphonate, 2E,6E-Farnesyl Bisphosphonate) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] | ||||||||
| ChEMBL | Inhibition of GST-tagged human recombinant GGDPS expressed in BL21 gold bacteria | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2008) 16: 390-399 [PMID:17905588] |
| ChEMBL | Inhibition of human recombinant GGDPS expressed in BL21 gold bacteria | B | 7 | pIC50 | 100 | nM | IC50 | Bioorg Med Chem (2008) 16: 3652-3660 [PMID:18308574] |
| squalene synthase in Human [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
| GtoPdb | Inhibition of Squalene Synthase | - | 7.74 | pIC50 | 18 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 2435-2440 |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | Inhibition rat liver microsomal squalene synthase | B | 7.49 | pIC50 | 32.4 | nM | IC50 | J Med Chem (1995) 38: 2596-2605 [PMID:7629799] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
