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ChEMBL ligand: CHEMBL478348 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Farnesyltransferase, putative in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5223] [UniProtKB: Q4Q5W4] | ||||||||
ChEMBL | Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | B | 6.01 | pIC50 | 970 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
Plasmodium falciparum (isolate K1 / Thailand) in Plasmodium falciparum K1 (target type: ORGANISM) [ChEMBL: CHEMBL612856] | ||||||||
ChEMBL | Antiplasmodial activity after 48 hrs against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 in human erythrocytes by [3H]hypoxanthine uptake | F | 5 | pIC50 | 10000 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
GtoPdb | Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter | - | 6.18 | pIC50 | 660 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4049-61 [PMID:17709461] |
ChEMBL | Inhibition of human recombinant squalene synthase expressed in Escherichia coli BL21(DE3 pLysS) by liquid scintillation counter | B | 6.18 | pIC50 | 660 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]