compound 2a (+) [PMID: 8709131] [Ligand Id: 3102] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL279261 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Farnesyltransferase, putative in Leishmania major (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5223] [UniProtKB: Q4Q5W4] | ||||||||
| ChEMBL | Inhibition of Leishmania major recombinant squalene synthase expressed in Escherichia coli by liquid scintillation counter | B | 7.89 | pIC50 | 13 | nM | IC50 | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
| Farnesyltransferase, putative in Trypanosoma cruzi (strain CL Brener) (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5220] [UniProtKB: Q4CXF7] | ||||||||
| ChEMBL | Inhibition of Trypanosoma cruzi squalene synthase | B | 7.21 | pKi | 62 | nM | Ki | Antimicrob Agents Chemother (2007) 51: 4049-4061 [PMID:17709461] |
| lanosterol synthase/Lanosterol synthase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3262] [GtoPdb: 2434] [UniProtKB: P48450] | ||||||||
| ChEMBL | Inhibition of compound was measured on rat microsomal Oxidosqualene-lanosterol cyclase | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
| squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
| ChEMBL | In vitro inhibition against rat microsomal squalene synthase (SS) | B | 6.92 | pIC50 | 121 | nM | IC50 | J Med Chem (1996) 39: 2971-2979 [PMID:8709131] |
| ChEMBL | In vitro inhibition against rat microsomal squalene synthase (SS) | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1996) 39: 2971-2979 [PMID:8709131] |
| ChEMBL | Compound was measured for the inhibition of rat microsomal squalene synthase enzyme | B | 7.8 | pIC50 | 16 | nM | IC50 | J Med Chem (1999) 42: 1306-1311 [PMID:10197973] |
| GtoPdb | In vitro inhibition against rat microsomal squalene synthase (SS) | - | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (1996) 39: 2971-9 [PMID:8709131] |
| ChEMBL | In vitro inhibition against rat microsomal squalene synthase (SS) | B | 8.15 | pIC50 | 7 | nM | IC50 | J Med Chem (1996) 39: 2971-2979 [PMID:8709131] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
