cimadronate [Ligand Id: 3174] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL56253 (YM-175) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] | ||||||||
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | - | 7.2 | pKi | 62.4 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 7.2 | pKi | 62.4 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
| ChEMBL | Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand | B | 7.8 | pKi | 16 | nM | Ki | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 8 | pKi | 10 | nM | Ki | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 8 | pKi | 10 | nM | Ki | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
| ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | B | 6.44 | pIC50 | 365.6 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 | - | 6.44 | pIC50 | 365.6 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase was determined | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
| ChEMBL | Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M) | B | 6.8 | pIC50 | 158.49 | nM | IC50 | J Med Chem (2003) 46: 5171-5183 [PMID:14613320] |
| GtoPdb | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | - | 7.21 | pIC50 | 61.1 | nM | IC50 | J Med Chem (2008) 51: 2187-95 [PMID:18327899] |
| ChEMBL | Inhibition of human recombinant FPPS expressed in Escherichia coli BL21 after 10 mins | B | 7.21 | pIC50 | 61.1 | nM | IC50 | J Med Chem (2008) 51: 2187-2195 [PMID:18327899] |
| Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] | ||||||||
| ChEMBL | Inhibitory activity against Leishmania major Farnesyl diphosphate synthase | B | 6.8 | pIC50 | 160 | nM | IC50 | J Med Chem (2004) 47: 175-187 [PMID:14695831] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
