ChEMBL ligand: CHEMBL416301
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324] There should be some charts here, you may need to enable JavaScript!
Farnesyl pyrophosphate synthase in Leishmania donovani [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7] There should be some charts here, you may need to enable JavaScript!
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
farnesyl diphosphate synthase/Farnesyl diphosphate synthase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1782] [GtoPdb: 644] [UniProtKB: P14324]
ChEMBL	Binding affinity towards farnesyl Pyrophosphate Synthase using [14C]- isopentenyl pyrophosphate as radioligand	B	6.13	pKi	740	nM	Ki	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase was determined	B	5.11	pIC50	7800	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
ChEMBL	Inhibitory activity against farnesyl Pyrophosphate Synthase expressed as #NAME? (M)	B	5.11	pIC50	7762.47	nM	IC50	J Med Chem (2003) 46: 5171-5183 [PMID:14613320]
Farnesyl pyrophosphate synthase in Leishmania donovani (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3693] [UniProtKB: Q0GKD7]
ChEMBL	Inhibitory activity against Leishmania major Farnesyl diphosphate synthase	B	5.11	pIC50	7750	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
geranylgeranyl diphosphate synthase/Geranylgeranyl pyrophosphate synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4769] [GtoPdb: 643] [UniProtKB: O95749]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	5.57	pIC50	2690	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
ChEMBL	Inhibition of human recombinant geranylgeranyl diphosphate synthase	B	5.6	pIC50	2511.89	nM	IC50	J Med Chem (2008) 51: 5594-5607 [PMID:18800762]
GtoPdb	Inhibition of human recombinant geranylgeranyl diphosphate synthase	-	5.6	pIC50	-	-	-	J Med Chem (2008) 51: 5594-607 [PMID:18800762]
ChEMBL	Inhibitory activity against the human recombinant geranylgeranyl diphosphate synthase (GGPPSase).	B	6.04	pIC50	920	nM	IC50	J Med Chem (2002) 45: 2185-2196 [PMID:12014956]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	In vitro growth inhibition against Plasmodium falciparum	F	5.97	pIC50	1070	nM	IC50	J Med Chem (2004) 47: 175-187 [PMID:14695831]
ChEMBL	Antimicrobial activity against Plasmodium falciparum	F	6	pIC50	1000	nM	IC50	Bioorg Med Chem (2010) 18: 2225-2231 [PMID:20185316]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]