ciprofibrate [Ligand Id: 3438] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL557555 (Ciprofibrate, Modalim, NSC-759617, WIN 35833, WIN-35833) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] | ||||||||
| ChEMBL | Transactivation of GAL4-fused PPARalpha LBD expressed in HepG2 cells after 20 hrs by luminescence assay | B | 6.05 | pEC50 | 900 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 2527-2533 [PMID:22381047] |
| ChEMBL | Transactivation of GAL4-fused PPARalpha ligand binding domain transfected in human HepG2 cells after 20 hrs by luciferase reporter gene assay | B | 6.05 | pEC50 | 900 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 6681-6687 [PMID:23031596] |
| GtoPdb | Transactivation of a GAL4-PPARα ligand binding domain construct. | - | 6.05 | pEC50 | 900 | nM | EC50 | Bioorg Med Chem Lett (2012) 22: 2527-33 [PMID:22381047] |
| Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2129] [GtoPdb: 593] [UniProtKB: P37230] | ||||||||
| ChEMBL | Agonist activity at rat PPARalpha in rat H4IIE cells assessed as gene induction | F | 5 | pEC50 | >10000 | nM | EC50 | Bioorg Med Chem Lett (2007) 17: 6773-6778 [PMID:18029176] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
