ChEMBL ligand: CHEMBL9194 (A-127722, Atrasentan)
ETA receptor/Endothelin receptor ET-A in Human [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101] ETA receptor/Endothelin receptor ET-A in Rat [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684] There should be some charts here, you may need to enable JavaScript!
ETB receptor/Endothelin receptor ET-B in Human [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530] Endothelin receptor ET-B in Pig [ChEMBL: CHEMBL3949] [UniProtKB: P35463] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ETA receptor/Endothelin receptor ET-A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL252] [GtoPdb: 219] [UniProtKB: P25101]
ChEMBL	Inhibitory activity against human Endothelin A receptor in chinese hamster ovary cells	B	10.47	pKi	0.03	nM	Ki	J Med Chem (1996) 39: 1039-1048 [PMID:8676339]
ChEMBL	Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane	B	10.47	pKi	0.03	nM	Ki	J Med Chem (2016) 59: 8168-8188 [PMID:27266371]
GtoPdb	CHO cells expressing human ETA receptor.	-	10.47	pKi	0.03	nM	Ki	J Pharmacol Exp Ther (1996) 276: 473-81 [PMID:8632312]; J Med Chem (1996) 39: 1039-48 [PMID:8676339]
ChEMBL	Displacement of [125I]ET-1 from Endothelin A receptor	B	9.51	pIC50	0.31	nM	IC50	J Med Chem (2004) 47: 1969-1986 [PMID:15055997]
ChEMBL	Binding affinity towards human Endothelin A receptor (hET -A)	B	10.1	pIC50	0.08	nM	IC50	J Med Chem (1999) 42: 3668-3678 [PMID:10479298]
ChEMBL	Displacement of [125I]ET-1 from human ET-A receptor expressed in CHO cell membrane	B	10.26	pIC50	0.06	nM	IC50	J Med Chem (2016) 59: 8168-8188 [PMID:27266371]
ChEMBL	Ability to displace endothelin ([125I]ET1) from human Endothelin A receptor	B	10.47	pIC50	0.03	nM	IC50	J Med Chem (1997) 40: 3217-3227 [PMID:9379441]
ChEMBL	Binding ability determined by the displacement of [125I]ET1 from the human endothelin A receptor	B	10.47	pIC50	0.03	nM	IC50	J Med Chem (1999) 42: 3679-3689 [PMID:10479299]
GtoPdb	-	-	9.2	pA2	-	-	-	J Pharmacol Exp Ther (1996) 276: 473-81 [PMID:8632312]
ETA receptor/Endothelin receptor ET-A in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4566] [GtoPdb: 219] [UniProtKB: P26684]
ChEMBL	binding affinity against human Endothelin A receptor	B	10.33	pKi	0.05	nM	Ki	J Med Chem (2001) 44: 3978-3984 [PMID:11689084]
ChEMBL	Binding affinity towards Endothelin A receptor	B	10.47	pKi	0.03	nM	Ki	J Med Chem (2004) 47: 1969-1986 [PMID:15055997]
ChEMBL	In vitro ability to inhibit specific [125I]ET1 binding to rat aorta membranes Endothelin A receptor	B	8.82	pIC50	1.5	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1771-1776 [PMID:9873432]
ChEMBL	Binding affinity towards endothelin A receptor in prolactin secreting rat pituitary cells using [125I]ET1 as radioligand.	B	9.4	pIC50	0.4	nM	IC50	J Med Chem (1997) 40: 322-330 [PMID:9022798]
ChEMBL	Binding affinity against Endothelin A receptor in MMQ cells in rat	B	9.44	pIC50	0.36	nM	IC50	J Med Chem (2001) 44: 3978-3984 [PMID:11689084]
ChEMBL	Inhibitory activity against the Endothelin A receptor of rat MMQ cells	B	9.51	pIC50	0.31	nM	IC50	J Med Chem (1996) 39: 1039-1048 [PMID:8676339]
ChEMBL	Ability to displace [125I]ET1 from the rat endothelin A receptor expressed in rat aorta smooth muscle cells.	B	9.51	pIC50	0.31	nM	IC50	J Med Chem (2004) 47: 2750-2760 [PMID:15139753]
ChEMBL	Inhibitory activity against human Endothelin A receptor	B	10.1	pIC50	0.08	nM	IC50	J Med Chem (2001) 44: 3978-3984 [PMID:11689084]
ETB receptor/Endothelin receptor ET-B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1785] [GtoPdb: 220] [UniProtKB: P24530]
GtoPdb	CHO cells expressing human ETB receptor.	-	6.86	pKi	138	nM	Ki	J Med Chem (1996) 39: 1039-48 [PMID:8676339]
ChEMBL	Binding affinity against endothelin B receptor in porcine cerebellar tissue	B	6.29	pIC50	515	nM	IC50	J Med Chem (2001) 44: 3978-3984 [PMID:11689084]
ChEMBL	Inhibitory activity against human endothelin B receptor	B	7.06	pIC50	88	nM	IC50	J Med Chem (2001) 44: 3978-3984 [PMID:11689084]
ChEMBL	Binding ability determined by the displacement of [125 I]ET-3 from the human Endothelin B receptor	B	7.2	pIC50	63.3	nM	IC50	J Med Chem (1999) 42: 3679-3689 [PMID:10479299]
Endothelin receptor ET-B in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3949] [UniProtKB: P35463]
ChEMBL	Binding affinity towards endothelin B receptor in porcine cerebellar tissue using [125I]-ET-1 as radioligand.	B	6.28	pIC50	520	nM	IC50	J Med Chem (1997) 40: 322-330 [PMID:9022798]
ChEMBL	Inhibitory activity measured against Endothelin B receptor binding to porcine cerebellum	B	6.72	pIC50	191	nM	IC50	J Med Chem (1996) 39: 1039-1048 [PMID:8676339]
ChEMBL	In vitro ability to inhibit specific [125I]ET1 binding to porcine kidney (inner medulla) membranes Endothelin B receptor	B	6.96	pIC50	110	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1771-1776 [PMID:9873432]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]