ChEMBL ligand: CHEMBL9946 (CP-154526)
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998] CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353] There should be some charts here, you may need to enable JavaScript!
CRF2 receptor/Corticotropin releasing factor receptor 2 in Rat [ChEMBL: CHEMBL3581] [GtoPdb: 213] [UniProtKB: P47866] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CRF1 receptor/Corticotropin releasing factor receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1800] [GtoPdb: 212] [UniProtKB: P34998]
ChEMBL	Displacement of [125I]0-CRF from human Corticotropin releasing factor receptor 1 expressed in CHO cells	B	7.25	pKi	56	nM	Ki	Bioorg Med Chem Lett (1998) 8: 2067-2070 [PMID:9873487]
ChEMBL	Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells	B	8.43	pKi	3.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3870-3873 [PMID:15990298]
ChEMBL	Binding affinity by displacement of [125I]Tyr-o-CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 human neuroblastoma cell.	B	8.43	pKi	3.7	nM	Ki	Bioorg Med Chem Lett (2003) 13: 3997-4000 [PMID:14592493]
ChEMBL	Antagonist activity at human CRF-1 receptor	F	8.52	pKi	3	nM	Ki	J Med Chem (2011) 54: 4187-4206 [PMID:21618986]
ChEMBL	Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells	B	8.52	pKi	3	nM	Ki	Bioorg Med Chem Lett (2008) 18: 4486-4490 [PMID:18672365]
ChEMBL	Displacement of [125I]sauvagine from CRF1 receptor expressed in human IMR32 cells	B	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (2008) 18: 891-896 [PMID:18180159]
ChEMBL	Displacement of [125I]-TYR-ovine CRH from cloned human corticotropin releasing factor receptor 1 expressed in 293 EBNA cells	B	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (1999) 9: 1057-1062 [PMID:10230640]
ChEMBL	Antagonistic activity for Corticotropin releasing factor receptor 1	F	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (1999) 9: 1063-1066 [PMID:10230641]
ChEMBL	Displacement of [125I]-sauvagine from Corticotropin releasing factor receptor 1 endogenously expressed in IMR-32 human neuroblastoma cells	B	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (2002) 12: 2133-2136 [PMID:12127521]
ChEMBL	Binding affinity against [125I]-Try0-o-Corticotropin-releasing Factor to Corticotropin releasing hormone receptor 1 from ovine	B	8.57	pKi	2.7	nM	Ki	J Med Chem (1997) 40: 1749-1754 [PMID:9171885]
ChEMBL	Displacement of [125I]-Tyr-o- CRF from human corticotropin releasing factor receptor 1 expressed in IMR-32 cells	B	8.57	pKi	2.7	nM	Ki	Bioorg Med Chem Lett (2005) 15: 3870-3873 [PMID:15990298]
ChEMBL	Binding affinity to recombinant human Corticotropin releasing factor receptor 1 (hCRF1) expressed in 293EBNA cells	B	8.79	pKi	1.61	nM	Ki	J Med Chem (1999) 42: 833-848 [PMID:10072681]
ChEMBL	Displacement of [125I]CRF from human recombinant CRF1 receptor expressed in CHO cell membrane	B	7.8	pIC50	15.85	nM	IC50	Bioorg Med Chem Lett (2007) 17: 5218-5221 [PMID:17629700]
ChEMBL	Displacement of ovine [125I]CRF from human CRF1 receptor expressed in CHO cells	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2365-2371 [PMID:21414781]
CRF1 receptor/Corticotropin releasing factor receptor 1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4649] [GtoPdb: 212] [UniProtKB: P35353]
ChEMBL	Inhibition of binding of 70 pM [125I]-Try0-o-Corticotropin-releasing Factor (CFR) to Corticotropin releasing hormone receptor 1 in Rat brain membrane	B	8.26	pIC50	5.5	nM	IC50	J Med Chem (1997) 40: 1749-1754 [PMID:9171885]
GtoPdb	-	-	10.41	pIC50	0.04	nM	IC50	Eur J Pharmacol (1996) 309: 195-200 [PMID:8874139]
CRF2 receptor/Corticotropin releasing factor receptor 2 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3581] [GtoPdb: 213] [UniProtKB: P47866]
ChEMBL	Inhibition of binding of [125I]-Tyr0-sauvagine to Corticotropin releasing hormone receptor 2 (CRF2)	B	5	pKi	>10000	nM	Ki	J Med Chem (1997) 40: 1749-1754 [PMID:9171885]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]